{"id":"W2009654816","doi":"10.1016/j.bbrc.2007.02.034","title":"Processing and trafficking of a prohormone convertase 2 active site mutant","year":2007,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse","keywords":"Proprotein Convertases; Furin; Prohormone convertase; Zymogen; Protein precursor; Proprotein convertase; Cleavage (geology); Secretory pathway; Mutant; Chemistry; Active site; Serine; Biochemistry; Subtilisin; Kexin; Serine protease; Cell biology; Prohormone; Biology; Endoplasmic reticulum; Golgi apparatus; Enzyme; Gene; Protease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002065422,0.0005226815,0.0003025006,0.0001943749,0.0003988981,0.0008196294,0.0007114809,0.0009900418,0.002008503],"category_scores_gemma":[0.0002922771,0.0002280253,0.000537587,0.0001870634,0.000341354,0.0003168185,0.000239521,0.001329173,0.001017925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008703488,"about_ca_system_score_gemma":0.0005110034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003748327,"about_ca_topic_score_gemma":0.001936379,"domain_scores_codex":[0.999813,0.00002542594,0.00003202455,0.00004403024,0.00005324519,0.0000322321],"domain_scores_gemma":[0.9996598,0.00011239,0.00007307293,0.00004678751,0.00003832823,0.00006957059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002765562,0.00005326423,0.00009524079,0.00002337237,0.000009027194,0.0004175018,0.00004040005,0.0002768877,0.9977478,0.000454142,0.0001136973,0.0004921126],"study_design_scores_gemma":[0.00005346471,0.00007836942,0.001582694,0.000007190968,0.00001916783,0.0009901519,0.00006676126,0.003687637,0.9906079,0.000121539,0.002768808,0.00001640458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993467,0.0002749152,0.003436099,0.0002909116,0.0001428519,0.00004292407,0.001076353,0.00009745014,0.00117153],"genre_scores_gemma":[0.9890715,0.0002055591,0.003254817,0.0001527438,0.00002266743,0.00003201315,0.0015827,0.0001350995,0.00554301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003748327,"threshold_uncertainty_score":0.007453024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03982245894421142,"score_gpt":0.340633226475438,"score_spread":0.3008107675312265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}