{"id":"W2009657693","doi":"10.1016/j.cellsig.2007.10.010","title":"Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells","year":2007,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; PI3K/AKT/mTOR pathway; Protein kinase B; Biology; Signal transduction; Insulin receptor; Cancer research; Insulin; Cell biology; Beta-catenin; mTORC2; Chromatin immunoprecipitation; Endocrinology; Internal medicine; Chemistry; Gene expression; mTORC1; Insulin resistance; Medicine; Promoter; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463274,0.0004707845,0.000297723,0.0006301383,0.0002977077,0.0007007879,0.0001697464,0.0002782492,0.001951223],"category_scores_gemma":[0.0001304474,0.0002568893,0.0003503633,0.0004182886,0.0002800459,0.0004344638,0.0003064931,0.0004669527,0.0005474313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005821363,"about_ca_system_score_gemma":0.000261427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009884579,"about_ca_topic_score_gemma":0.001347551,"domain_scores_codex":[0.9997963,0.00002509596,0.00002111718,0.00004230655,0.00005574227,0.00005940687],"domain_scores_gemma":[0.9999113,0.000008463477,0.00003111608,0.000006655887,0.00001598584,0.00002653673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004530539,0.00001325233,0.0008561737,0.0001404953,0.00001445414,0.000203576,0.00001795349,0.00004923717,0.9939262,0.0006502562,0.000106254,0.003569099],"study_design_scores_gemma":[0.00003042533,0.0001381542,0.03079665,0.00002139236,0.0000750973,0.001102898,0.00008625448,0.0006616966,0.9572849,0.0002271112,0.009565592,0.000009755526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610434,0.02267014,0.006195403,0.0004214411,0.00008022943,0.00004887648,0.001859106,0.0003017001,0.00737976],"genre_scores_gemma":[0.9821392,0.006340483,0.002478477,0.0000741397,0.00002632036,0.00004267664,0.001623794,0.00003383348,0.007241073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001951223,"threshold_uncertainty_score":0.006527483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01841245144459574,"score_gpt":0.2279416973124664,"score_spread":0.2095292458678707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}