{"id":"W2009660891","doi":"10.1021/pr800810n","title":"Proteomic Investigation of Phosphorylation Sites in Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase","year":2008,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Phosphorylation; Poly ADP ribose polymerase; Protein phosphorylation; Biology; Serine; Biochemistry; Phosphorylation cascade; DNA damage; Polymerase; Kinase; Proteomics; Cell biology; Enzyme; Protein kinase A; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003090352,0.0002333989,0.0006501407,0.001667825,0.0001882542,0.00003367512,0.0002111549,0.0002343917,0.0002005414],"category_scores_gemma":[0.0006713757,0.0002053066,0.0001429888,0.001350994,0.0007075692,0.0005395075,0.00007406239,0.001286584,0.00001725953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005281561,"about_ca_system_score_gemma":0.001287506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003229617,"about_ca_topic_score_gemma":0.000007383119,"domain_scores_codex":[0.9956513,0.0005514864,0.001177194,0.0003245706,0.001746523,0.0005489118],"domain_scores_gemma":[0.9974368,0.0002408343,0.0006233369,0.0003468508,0.0009160383,0.0004361327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002606073,0.0002131912,0.09840178,0.0002612241,0.00007052751,0.0002242311,0.001512406,0.000006936231,0.8943961,0.00003917671,0.0007519223,0.001516381],"study_design_scores_gemma":[0.005996549,0.001995613,0.1140902,0.0009935166,0.00002243057,0.001030779,0.0001483203,0.0003914514,0.8735227,0.001336939,0.0002876841,0.0001838533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870715,0.004571115,0.0001827656,0.006334902,0.00009120975,0.001530796,0.00001655392,0.00001691065,0.0001842362],"genre_scores_gemma":[0.9939913,0.0008517674,0.003768409,0.0001154245,0.0007655147,0.00008770558,0.00001149852,0.0000471919,0.0003611732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02087346,"threshold_uncertainty_score":0.837216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034420127235248,"score_gpt":0.3800537402206966,"score_spread":0.2766117274971718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}