{"id":"W2009681469","doi":"10.1074/jbc.m112.394023","title":"The M2 Module of the Cys-His-rich Domain (CHRD) of PCSK9 Protein Is Needed for the Extracellular Low-density Lipoprotein Receptor (LDLR) Degradation Pathway","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"LDL receptor; PCSK9; Extracellular; Chemistry; Receptor; Degradation (telecommunications); Low-density lipoprotein; Domain (mathematical analysis); Cell biology; Lipoprotein; Biochemistry; Cholesterol; Biology; Computer science; Telecommunications","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009031707,0.0005004403,0.0002431538,0.0001981256,0.0001697212,0.0002199871,0.0002848876,0.0002813321,0.001471683],"category_scores_gemma":[0.0001256697,0.0001809692,0.0004544972,0.000226975,0.000263948,0.0001462284,0.0003375936,0.0006215613,0.0007646963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004159664,"about_ca_system_score_gemma":0.0002339497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007378721,"about_ca_topic_score_gemma":0.0006073713,"domain_scores_codex":[0.9998766,0.00001682702,0.00001487135,0.00003246786,0.00003853286,0.0000207122],"domain_scores_gemma":[0.999872,0.00001691334,0.00005026089,0.00001916708,0.000009429719,0.00003225599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001540663,0.00002189702,0.0005165928,0.0000326584,0.00001055587,0.0001417224,0.00001550036,0.0001262099,0.9975867,0.0001240228,0.00003794288,0.001232045],"study_design_scores_gemma":[0.00002637918,0.0001133267,0.007629792,0.000006002643,0.0000208927,0.0008058082,0.00002958789,0.001095884,0.9857846,0.00004570215,0.004432953,0.000009086101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922584,0.0002329454,0.005835623,0.00005453963,0.00002495325,0.0000297263,0.0009737769,0.00007560352,0.0005144339],"genre_scores_gemma":[0.9881443,0.0001551905,0.006863022,0.00003362417,0.000007753217,0.00003095304,0.00198832,0.00004416009,0.002732629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001471683,"threshold_uncertainty_score":0.004923224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234841622482943,"score_gpt":0.2424618245242434,"score_spread":0.2201134082994139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}