{"id":"W2009699519","doi":"10.1016/j.bmcl.2007.05.056","title":"Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 1: Substituted pyrazoles","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Fastidious organism; Chemistry; Gram; Stereochemistry; Antibacterial activity; Aryl; Chemical synthesis; Pyrazole; Structure–activity relationship; Gram-positive bacteria; Antibacterial agent; Gram-negative bacteria; Combinatorial chemistry; Alkyl; In vitro; Bacteria; Antimicrobial; Organic chemistry; Biochemistry; Antibiotics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371726,0.0004043699,0.000271005,0.000104984,0.0001360416,0.0002105738,0.0004018471,0.0002113013,0.00190092],"category_scores_gemma":[0.0001352712,0.0001385601,0.0001621384,0.0001557261,0.0001960377,0.0002032889,0.0002082015,0.0002922191,0.0004675693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002378878,"about_ca_system_score_gemma":0.000343644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000467718,"about_ca_topic_score_gemma":0.00113555,"domain_scores_codex":[0.9999622,0.000006329079,0.000004093795,0.000004228381,0.000006426787,0.00001675875],"domain_scores_gemma":[0.9999586,0.000007121354,0.00001406492,0.00000471017,0.000004840154,0.00001062148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001136753,0.0001830319,0.0002859287,0.0004879445,0.00001657075,0.0005564496,0.0001324156,0.003604679,0.9576812,0.001429152,0.001166672,0.03331925],"study_design_scores_gemma":[0.001391072,0.01129767,0.007972935,0.00009270207,0.0001314948,0.002391119,0.0001233693,0.004261333,0.9220005,0.0007713904,0.04947762,0.00008880314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769824,0.009428231,0.006192604,0.0002682496,0.0001120136,0.0001486527,0.0006884317,0.0001528297,0.006026632],"genre_scores_gemma":[0.9791986,0.009660849,0.005235321,0.00015062,0.00003692706,0.0001172891,0.001208838,0.00001701874,0.004374567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00190092,"threshold_uncertainty_score":0.00635916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381263692434742,"score_gpt":0.2365190857532559,"score_spread":0.2227064488289084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}