{"id":"W2009712656","doi":"10.1002/eji.201142071","title":"T cells interact with T cells via CD40‐CD154 to promote autoimmunity in type 1 diabetes","year":2012,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; American Diabetes Association","keywords":"CD154; CD40; Biology; clone (Java method); T cell; Interleukin 21; Cell biology; CD28; Antigen-presenting cell; IL-2 receptor; Flow cytometry; Pancreatic islets; Cytotoxic T cell; Molecular biology; Immunology; In vitro; Immune system; Islet; Endocrinology; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003754175,0.0007536626,0.0004574576,0.0004356349,0.0002184609,0.0004839879,0.0001934478,0.0004936756,0.001646334],"category_scores_gemma":[0.0001366362,0.0001915799,0.000359558,0.0001853028,0.0002071151,0.0002978497,0.00028864,0.001111074,0.0005743163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000301963,"about_ca_system_score_gemma":0.0001856103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002278616,"about_ca_topic_score_gemma":0.000391205,"domain_scores_codex":[0.9996754,0.00009677696,0.00002340877,0.00004322812,0.00007007516,0.00009124273],"domain_scores_gemma":[0.9999154,0.00001871378,0.00001665575,0.000009259258,0.000008889592,0.00003106957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001507796,0.000108197,0.0002991208,0.00006607693,0.000005999719,0.0001067562,0.0000192245,0.00008007777,0.9963542,0.00008741131,0.00006334081,0.00265873],"study_design_scores_gemma":[0.0002608504,0.002567925,0.01270639,0.00007613948,0.0001207685,0.001472395,0.00008457912,0.002234004,0.9685743,0.0003502319,0.01153474,0.00001758669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879315,0.007954307,0.00130747,0.0001853529,0.00007470194,0.00003151598,0.00009572428,0.00007088216,0.002348492],"genre_scores_gemma":[0.9893463,0.00458076,0.002684195,0.0002280172,0.0001228532,0.00006004512,0.0001946609,0.00002832092,0.002754672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646334,"threshold_uncertainty_score":0.005507529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003638112076368,"score_gpt":0.2125937900578578,"score_spread":0.2025574089370941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}