{"id":"W2009712656","doi":"10.1002/eji.201142071","title":"T cells interact with T cells via CD40‐CD154 to promote autoimmunity in type 1 diabetes","year":2012,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; American Diabetes Association","keywords":"CD154; CD40; Biology; clone (Java method); T cell; Interleukin 21; Cell biology; CD28; Antigen-presenting cell; IL-2 receptor; Flow cytometry; Pancreatic islets; Cytotoxic T cell; Molecular biology; Immunology; In vitro; Immune system; Islet; Endocrinology; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001213505,0.000255366,0.0004479147,0.0004854698,0.0001084012,0.00002226819,0.0004313437,0.0001028358,0.001582804],"category_scores_gemma":[0.00009693197,0.0001988078,0.0001090022,0.0003109772,0.000140777,0.0004138829,0.000146291,0.001189339,0.003787275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001210145,"about_ca_system_score_gemma":0.00004965424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001682617,"about_ca_topic_score_gemma":0.000002773831,"domain_scores_codex":[0.9970683,0.001382764,0.0007530933,0.0001617206,0.00005009303,0.000583998],"domain_scores_gemma":[0.9987513,0.0001142999,0.0005016161,0.0003358521,0.0002463152,0.00005058087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001115204,0.0004027279,0.0009905269,0.000007863624,0.000268328,0.00002774826,0.001758169,0.00003028581,0.9773472,0.00001047386,0.004292779,0.01374868],"study_design_scores_gemma":[0.001674762,0.003129873,0.02852797,0.0001628737,0.00004723557,0.0005043698,0.000453702,0.000002341583,0.6165848,0.000002741926,0.3486439,0.0002654408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828247,0.003133268,0.0003712481,0.0002342843,0.01024139,0.0001628217,0.00000124096,0.0000316606,0.002999387],"genre_scores_gemma":[0.9959716,0.0001275974,0.0003769212,0.0004091686,0.00009597014,0.00000154004,0.00001108461,0.00004661052,0.002959568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3607624,"threshold_uncertainty_score":0.9993299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003638112076368,"score_gpt":0.2125937900578578,"score_spread":0.2025574089370941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}