{"id":"W2009734791","doi":"10.4161/auto.21211","title":"ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy","year":2012,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Mitophagy; Mitochondrion; Cell biology; Parkin; Autophagy; Mitochondrial ROS; Reactive oxygen species; Biology; PINK1; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002023088,0.000538811,0.0006476351,0.0002482621,0.0003094116,0.0001074439,0.0002682972,0.0004924992,0.001105255],"category_scores_gemma":[0.0002104557,0.0005109305,0.0003050335,0.0004163425,0.00009180367,0.0008315475,0.00008444324,0.0004534586,0.0004412216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446086,"about_ca_system_score_gemma":0.0002744736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001666928,"about_ca_topic_score_gemma":0.000009207188,"domain_scores_codex":[0.9964693,0.0002339915,0.0007918858,0.0006413498,0.0008698238,0.0009936094],"domain_scores_gemma":[0.99793,0.0001633559,0.0003435265,0.0007322094,0.0001691367,0.0006617267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008668281,0.001393698,0.003861333,0.00007098337,0.000459143,0.00007108163,0.000635947,0.000006144545,0.9721098,0.001665995,0.00733608,0.01152299],"study_design_scores_gemma":[0.007124573,0.0004998239,0.02871126,0.00007856424,0.0005442611,0.0001466341,0.00008923127,0.0005316101,0.9490609,0.0003400722,0.01218705,0.0006860518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798263,0.00439338,0.005310412,0.0003079871,0.005817099,0.001307816,0.00008595868,0.0005635079,0.002387479],"genre_scores_gemma":[0.9894949,0.0001470737,0.001997263,0.001381215,0.003472557,0.0001949526,0.001006539,0.0001290786,0.002176474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02484992,"threshold_uncertainty_score":0.9998079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930266154329435,"score_gpt":0.2813854675212044,"score_spread":0.2620828059779101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}