{"id":"W2009734791","doi":"10.4161/auto.21211","title":"ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy","year":2012,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Mitophagy; Mitochondrion; Cell biology; Parkin; Autophagy; Mitochondrial ROS; Reactive oxygen species; Biology; PINK1; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001754648,0.0002435807,0.0003169955,0.0001668951,0.0001424723,0.0002577229,0.0001097566,0.0002836077,0.0006750479],"category_scores_gemma":[0.0001022225,0.0001337099,0.000328146,0.0001303623,0.0001884054,0.000401418,0.0003111461,0.0006071803,0.0002155902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001842116,"about_ca_system_score_gemma":0.00008481671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001831279,"about_ca_topic_score_gemma":0.000287129,"domain_scores_codex":[0.9998555,0.00002132403,0.00001489975,0.00003509159,0.00003288553,0.00004020103],"domain_scores_gemma":[0.9998922,0.00002041756,0.00003631308,0.00001261789,0.00001147522,0.00002687531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000145032,0.00001889013,0.0001944908,0.00003251243,0.000005553805,0.0001704533,0.00001967868,0.00003396221,0.9987822,0.00005110546,0.00002257365,0.0005235747],"study_design_scores_gemma":[0.00002450703,0.000320683,0.01118682,0.000009666818,0.00001164565,0.0006895952,0.00006193307,0.001062038,0.9850175,0.000127478,0.001481027,0.00000713651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932045,0.00207637,0.003685614,0.0001027733,0.00003527768,0.00002980477,0.0001628927,0.00004427695,0.0006583629],"genre_scores_gemma":[0.9959316,0.0009203778,0.00183063,0.00007830063,0.00001576245,0.00002476895,0.0002329435,0.00001095463,0.0009546063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006750479,"threshold_uncertainty_score":0.002258301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930266154329435,"score_gpt":0.2813854675212044,"score_spread":0.2620828059779101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}