{"id":"W2009792376","doi":"10.1016/j.bmcl.2007.09.062","title":"Synthesis, antibacterial activity, and quantitative structure–activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" altimg=\"si2.gif\" overflow=\"scroll\"><mml:mrow><mml:mn>2</mml:mn><mml:mi>H</mml:mi></mml:mrow></mml:math>)-benzofuranone derivatives","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"","keywords":"Chemistry; Bacillus subtilis; Staphylococcus epidermidis; Klebsiella pneumoniae; Gram-positive bacteria; Antibacterial activity; Bacteria; Nitroimidazole; Gram; Quantitative structure–activity relationship; Stereochemistry; Antibacterial agent; Structure–activity relationship; Staphylococcus aureus; Escherichia coli; Organic chemistry; Biochemistry; Antibiotics; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396363,0.0002309736,0.000177727,0.0002480922,0.00009618446,0.0001626098,0.0002030077,0.0001582249,0.002696244],"category_scores_gemma":[0.0002491026,0.0001773539,0.0002059222,0.0001669795,0.0001701533,0.0002254436,0.0001050899,0.0002557961,0.0004239937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003390926,"about_ca_system_score_gemma":0.0002525147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056305,"about_ca_topic_score_gemma":0.002530629,"domain_scores_codex":[0.9999062,0.00002470041,0.00001054217,0.00001823241,0.00002035914,0.00002005687],"domain_scores_gemma":[0.9998949,0.0000247751,0.00003174501,0.00001270086,0.00001663458,0.00001923424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005218622,0.0001506674,0.0002797967,0.0001193377,0.00001621787,0.00003938545,0.00003812592,0.0009686459,0.9869412,0.0003710118,0.0002645325,0.01028916],"study_design_scores_gemma":[0.0001271427,0.002783141,0.004400192,0.00001455459,0.00003700022,0.0001517245,0.00001662262,0.001571186,0.9864093,0.00008289241,0.004391623,0.00001454768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771869,0.009401426,0.006110598,0.0002393709,0.00004468075,0.0001603333,0.001869194,0.0001091847,0.004878263],"genre_scores_gemma":[0.983639,0.003952655,0.004929737,0.00008345224,0.00002296384,0.0001136655,0.001501746,0.00001812936,0.005738697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002696244,"threshold_uncertainty_score":0.009019852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0271254541325098,"score_gpt":0.2465360343276425,"score_spread":0.2194105801951327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}