{"id":"W2009792376","doi":"10.1016/j.bmcl.2007.09.062","title":"Synthesis, antibacterial activity, and quantitative structure–activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" altimg=\"si2.gif\" overflow=\"scroll\"><mml:mrow><mml:mn>2</mml:mn><mml:mi>H</mml:mi></mml:mrow></mml:math>)-benzofuranone derivatives","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"","keywords":"Chemistry; Bacillus subtilis; Staphylococcus epidermidis; Klebsiella pneumoniae; Gram-positive bacteria; Antibacterial activity; Bacteria; Nitroimidazole; Gram; Quantitative structure–activity relationship; Stereochemistry; Antibacterial agent; Structure–activity relationship; Staphylococcus aureus; Escherichia coli; Organic chemistry; Biochemistry; Antibiotics; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008343982,0.0004463679,0.0003284722,0.00007763394,0.0004469127,0.0001495455,0.0005664946,0.000929755,0.01581269],"category_scores_gemma":[0.002249647,0.0005804513,0.0003760247,0.0003239178,0.0009048254,0.0003943521,0.0003996467,0.0009075007,0.00004090812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002463136,"about_ca_system_score_gemma":0.0003350931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00052485,"about_ca_topic_score_gemma":0.00009690113,"domain_scores_codex":[0.9967892,0.0001272696,0.0006233324,0.0008315543,0.0008564325,0.0007722751],"domain_scores_gemma":[0.9958951,0.002020083,0.0009320663,0.0006948687,0.00005533314,0.0004025577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001289717,0.000161973,0.0001807792,0.0005864858,0.0005290926,0.0001510777,0.0005081073,0.000005423484,0.9805177,0.01112259,0.002852546,0.00209455],"study_design_scores_gemma":[0.0007425655,0.0001562932,0.003378727,0.0004280611,0.0003897022,0.0002412149,0.0007559137,0.001037668,0.9920301,0.00003924805,0.0002705054,0.0005300299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895446,0.0002801649,0.0003955031,0.0009211374,0.000285759,0.00002420347,0.0001823432,0.00009253652,0.008273719],"genre_scores_gemma":[0.9971689,0.0001562917,0.001097587,0.0002669826,0.001003482,0.0000328598,0.0001329809,0.0001139402,0.00002695738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01577179,"threshold_uncertainty_score":0.9996647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0271254541325098,"score_gpt":0.2465360343276425,"score_spread":0.2194105801951327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}