{"id":"W2009822728","doi":"10.1089/10430340050032438","title":"Protease-Deleted Adenovirus Vectors and Complementing Cell Lines: Potential Applications of Single-Round Replication Mutants for Vaccination and Gene Therapy","year":2000,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Research Canada; Institut National de la Recherche Scientifique","funders":"Medical Research Council; National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Medical Research Council Canada","keywords":"Biology; Mutant; Genetic enhancement; Gene; Viral vector; Transgene; Cell culture; Viral replication; Molecular biology; Virus; Virology; Vector (molecular biology); HEK 293 cells; Cell biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003674622,0.0002042226,0.0001911599,0.0000949012,0.0002972484,0.00005096332,0.0001919178,0.0001172512,0.0001270451],"category_scores_gemma":[0.000005211837,0.000205111,0.00006626494,0.0001320755,0.00007760736,0.00001084076,0.0000282539,0.0000641889,0.000001540427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001950599,"about_ca_system_score_gemma":0.00004341892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002499317,"about_ca_topic_score_gemma":0.00002464772,"domain_scores_codex":[0.998532,0.0001042963,0.0003561339,0.0005651257,0.0001757257,0.0002667094],"domain_scores_gemma":[0.9989771,0.00001628613,0.0001775063,0.0005559417,0.000198575,0.00007464607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001256747,0.0002266858,0.0003137348,0.00002233516,0.00006662279,2.787319e-7,0.0001159725,0.00003903051,0.89543,0.000004361108,0.00003326598,0.102491],"study_design_scores_gemma":[0.003075085,0.002807264,0.003514764,0.000004442625,0.00001168693,0.000008302713,0.00003131326,0.0002099328,0.9867459,0.0002173335,0.003160115,0.0002138947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910295,0.004653378,0.002009843,0.00006191136,0.00001372659,0.00208265,0.00007445317,0.00002479255,0.0000497503],"genre_scores_gemma":[0.9944289,0.002875144,0.001040261,0.0001149955,0.0002870384,0.0004960297,0.0004765621,0.00005835026,0.0002227483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1022771,"threshold_uncertainty_score":0.8364184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.040642420919175,"score_gpt":0.321989845610361,"score_spread":0.281347424691186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}