{"id":"W2009822728","doi":"10.1089/10430340050032438","title":"Protease-Deleted Adenovirus Vectors and Complementing Cell Lines: Potential Applications of Single-Round Replication Mutants for Vaccination and Gene Therapy","year":2000,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Research Canada; Institut National de la Recherche Scientifique","funders":"Medical Research Council; National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Medical Research Council Canada","keywords":"Biology; Mutant; Genetic enhancement; Gene; Viral vector; Transgene; Cell culture; Viral replication; Molecular biology; Virus; Virology; Vector (molecular biology); HEK 293 cells; Cell biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005343696,0.0005537957,0.0004667123,0.0004244328,0.0001439915,0.0005668503,0.0005069475,0.000555282,0.0007312462],"category_scores_gemma":[0.0002487397,0.0002469589,0.0003310399,0.0002740601,0.0003039374,0.0004328161,0.0002460796,0.0007293115,0.0005005131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002995447,"about_ca_system_score_gemma":0.0002549461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002854959,"about_ca_topic_score_gemma":0.0003901766,"domain_scores_codex":[0.99977,0.00004427508,0.00002514196,0.00004387413,0.0000909329,0.00002580029],"domain_scores_gemma":[0.99984,0.00004231941,0.00003375587,0.00003155685,0.00002289972,0.0000294841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007462099,0.00002730125,0.0001251709,0.00009483218,0.000005846719,0.00004517807,0.00002105257,0.0001045361,0.9923252,0.0006127798,0.0001200575,0.00644347],"study_design_scores_gemma":[0.00002345007,0.0003273411,0.0006260323,0.00001199026,0.00002479448,0.0006756076,0.0000114722,0.001153782,0.983327,0.0002132321,0.01359268,0.00001268857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7172717,0.02849732,0.2453673,0.0005906009,0.0003989837,0.0007145355,0.001792234,0.0009939623,0.004373339],"genre_scores_gemma":[0.8093162,0.018968,0.156392,0.0001629524,0.00009337344,0.0003783872,0.003450382,0.0001756587,0.01106298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007312462,"threshold_uncertainty_score":0.002826035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.040642420919175,"score_gpt":0.321989845610361,"score_spread":0.281347424691186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}