{"id":"W2009839518","doi":"10.1002/adfm.201002497","title":"Amino Acid Pairing for De Novo Design of Self‐Assembling Peptides and Their Drug Delivery Potential","year":2011,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"Supramolecular Self-Assembly in Materials","field":"Materials Science","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Hydrogen bond; Amino acid; Peptide; Nanomedicine; Self-assembly; Drug delivery; Materials science; Hydrophobic effect; Ionic bonding; Pairing; Aqueous solution; Combinatorial chemistry; Nanotechnology; Chemistry; Molecule; Organic chemistry; Biochemistry; Ion; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001506231,0.000335197,0.0005154616,0.0001343649,0.000212864,0.0001127343,0.000262244,0.0001260851,0.0003616005],"category_scores_gemma":[0.0001951857,0.0003009805,0.00008500971,0.00008938443,0.00009929294,0.0005634919,0.0001510871,0.00004664387,0.00002765669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007843223,"about_ca_system_score_gemma":0.0001159489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003277669,"about_ca_topic_score_gemma":0.000002133572,"domain_scores_codex":[0.9977357,0.0002868863,0.0006588901,0.0005285655,0.0002262635,0.0005637451],"domain_scores_gemma":[0.9986171,0.0002945922,0.0003763314,0.0003198018,0.0002750921,0.0001170886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009435479,0.00009158556,0.00007481199,0.0001671568,0.00005007944,0.000007302765,0.0005445749,0.0005035622,0.9968918,0.0004859632,0.00003573661,0.0002038554],"study_design_scores_gemma":[0.0009067748,0.0001875504,0.001471007,0.00007778509,0.00006425525,0.00007510986,0.0003449118,0.00007767684,0.991425,0.005015489,0.00003854773,0.0003159201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8808283,0.0001626511,0.1165373,0.00001521954,0.001537806,0.0005842345,0.0001240209,0.0001868566,0.0000236182],"genre_scores_gemma":[0.8687395,0.00004884164,0.130589,0.00009061314,0.0002233718,0.0002124416,0.00002310108,0.00005784427,0.00001528192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01405176,"threshold_uncertainty_score":0.9999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02775799099853233,"score_gpt":0.2243532473219795,"score_spread":0.1965952563234472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}