{"id":"W2009861617","doi":"10.1002/ddr.10080","title":"Role of amyloid β peptides in the regulation of central cholinergic function and its relevance to Alzheimer's disease pathology","year":2002,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Cholinergic; Basal forebrain; Cholinergic neuron; Neuroscience; Neurodegeneration; Senile plaques; Alzheimer's disease; Amyloid precursor protein; Acetylcholine; Biology; Biochemistry of Alzheimer's disease; Tau protein; Hyperphosphorylation; Hippocampus; Internal medicine; Endocrinology; Cell biology; Phosphorylation; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019459,0.0004963339,0.0007324332,0.0008202029,0.0001726922,0.0007739866,0.0004430945,0.0005664779,0.001194209],"category_scores_gemma":[0.0001459062,0.000119899,0.0002207532,0.000866598,0.0002289346,0.0005402358,0.0003260744,0.0005595002,0.0006458031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003095377,"about_ca_system_score_gemma":0.000479817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000568113,"about_ca_topic_score_gemma":0.0006023711,"domain_scores_codex":[0.9999238,0.00001141632,0.00001383519,0.00001548481,0.00002422822,0.00001124278],"domain_scores_gemma":[0.9999235,0.00002080761,0.00001626405,0.000002196342,0.00002730902,0.000009962885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003530739,0.0001824424,0.0008092494,0.03205537,0.0001682798,0.00243493,0.000440192,0.001629587,0.0919284,0.006933515,0.01622454,0.8468404],"study_design_scores_gemma":[0.00003917572,0.0008585353,0.008640881,0.003462185,0.0002459893,0.005507915,0.0003417627,0.0004634992,0.0110479,0.0051158,0.9642198,0.00005668214],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.00156453,0.9964995,0.0002135454,0.0001179829,0.0001875762,0.000004385157,0.00001778187,0.000006307115,0.001388314],"genre_scores_gemma":[0.004937174,0.9935299,0.0001775124,0.0001064134,0.0002741095,0.000007287333,0.00003245581,0.000001417877,0.0009338115],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001194209,"threshold_uncertainty_score":0.003995001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0508094324316032,"score_gpt":0.325528908429917,"score_spread":0.2747194759983138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}