{"id":"W2009863844","doi":"10.1021/ac900166a","title":"Differential <sup>12</sup>C-/<sup>13</sup>C-Isotope Dansylation Labeling and Fast Liquid Chromatography/Mass Spectrometry for Absolute and Relative Quantification of the Metabolome","year":2009,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":396,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Genome Alberta; Canada Research Chairs; Genome Canada","keywords":"Chemistry; Chromatography; Derivatization; Metabolite; Dansyl chloride; Mass spectrometry; Metabolome; Reagent; Electrospray ionization; Metabolomics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236071,0.0002912292,0.0004440976,0.00006746056,0.0002039369,0.00004635548,0.000207001,0.0002469278,0.0000243772],"category_scores_gemma":[0.0002889667,0.0002320107,0.0002245316,0.0002765523,0.0002741381,0.00001724297,0.0001136051,0.0001937893,5.441557e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001506275,"about_ca_system_score_gemma":0.00003361941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007324699,"about_ca_topic_score_gemma":0.000001773797,"domain_scores_codex":[0.9983489,0.00004175597,0.0004586204,0.0005947013,0.0002117245,0.0003442837],"domain_scores_gemma":[0.999044,0.00006770379,0.0002062685,0.0004281298,0.0001406515,0.0001132666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002050706,0.0000967763,0.001900097,0.00009495143,0.0003631824,4.827551e-7,0.00007625126,0.000129384,0.9947792,0.001931845,0.0001549015,0.0002678562],"study_design_scores_gemma":[0.001961153,0.0005777029,0.01872323,0.00006533741,0.000814349,0.00001989352,0.0004225531,0.02679008,0.9450563,0.002663268,0.00224011,0.0006660673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984507,0.001921903,0.01172291,0.000572333,0.00002421924,0.0002899906,0.00009016101,0.00001564321,0.0008558386],"genre_scores_gemma":[0.9965284,0.0008428715,0.001683884,0.00006098807,0.0002038596,0.00001703854,0.0001173448,0.00002149506,0.0005241529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04972294,"threshold_uncertainty_score":0.9461123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116454699593405,"score_gpt":0.2445839060986475,"score_spread":0.2334193591027134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}