{"id":"W2009863844","doi":"10.1021/ac900166a","title":"Differential <sup>12</sup>C-/<sup>13</sup>C-Isotope Dansylation Labeling and Fast Liquid Chromatography/Mass Spectrometry for Absolute and Relative Quantification of the Metabolome","year":2009,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":396,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Genome Alberta; Canada Research Chairs; Genome Canada","keywords":"Chemistry; Chromatography; Derivatization; Metabolite; Dansyl chloride; Mass spectrometry; Metabolome; Reagent; Electrospray ionization; Metabolomics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009888617,0.001163165,0.0006469335,0.0003980119,0.0002703451,0.0007339802,0.0009165394,0.0008658742,0.001491311],"category_scores_gemma":[0.0009537044,0.0004620056,0.0005619983,0.0005155892,0.0008949912,0.000898333,0.0005941619,0.001443727,0.001399746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005996916,"about_ca_system_score_gemma":0.0005552645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00060586,"about_ca_topic_score_gemma":0.001164412,"domain_scores_codex":[0.9990361,0.0001420068,0.00007331162,0.0002409285,0.0004439022,0.00006376645],"domain_scores_gemma":[0.9992074,0.0001689892,0.0002152505,0.0001394811,0.0002248433,0.00004398888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007798052,0.000009005294,0.0001612753,0.00006862659,0.000009322323,0.00004155147,0.00001317684,0.000153282,0.9933358,0.000330654,0.0001274143,0.005671787],"study_design_scores_gemma":[0.000003657325,0.00005526587,0.0004118091,0.000003517903,0.00001077543,0.0001510916,0.000005957726,0.001647715,0.9938367,0.00009912769,0.003765126,0.000009204585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2703988,0.007565742,0.709255,0.000876554,0.0004665812,0.0004458468,0.002520256,0.00178529,0.006686047],"genre_scores_gemma":[0.3733817,0.005238626,0.6068632,0.0008841253,0.0001649861,0.0007219001,0.004369454,0.0004486271,0.007927304],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001491311,"threshold_uncertainty_score":0.005229652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116454699593405,"score_gpt":0.2445839060986475,"score_spread":0.2334193591027134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}