{"id":"W2009870147","doi":"10.1136/annrheumdis-2012-eular.1965","title":"LB0005 12-week results of a phase 2B dose-ranging study of LY3009104 (INCB028050), an oral JAK1/JAK2 inhibitor, in combination with traditional dmards in patients with rheumatoid arthritis","year":2012,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Medicine; Rheumatoid arthritis; Methotrexate; Internal medicine; Placebo; Clinical endpoint; Randomized controlled trial; Gastroenterology; Dose-ranging study; Double blind","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002137944,0.001666697,0.003005633,0.0007207411,0.0006497976,0.001030049,0.001393524,0.002267034,0.006331408],"category_scores_gemma":[0.001616847,0.0007545979,0.001962321,0.0004282148,0.001091287,0.001152405,0.0004760253,0.005480938,0.002090271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00084124,"about_ca_system_score_gemma":0.001264421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002268473,"about_ca_topic_score_gemma":0.005092872,"domain_scores_codex":[0.9992672,0.0003154429,0.00005223154,0.00009288237,0.00008939117,0.0001829371],"domain_scores_gemma":[0.9988844,0.0002255485,0.0001472124,0.0001016632,0.00009323366,0.0005479835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6590437,0.1134025,0.004009395,0.0007594582,0.001795275,0.00035887,0.0002252359,0.003025315,0.05830335,0.0002426694,0.01101076,0.1478234],"study_design_scores_gemma":[0.4272085,0.5331998,0.0234449,0.0000643191,0.001064153,0.0003821694,0.00006578513,0.00156531,0.006880932,0.0002017853,0.005850951,0.00007134224],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720771,0.007155502,0.001851853,0.001715188,0.0004849716,0.002474013,0.006054514,0.0006980862,0.00748879],"genre_scores_gemma":[0.9683166,0.002693348,0.002838707,0.002469917,0.0004037587,0.001853774,0.0128981,0.0001260177,0.008399744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006331408,"threshold_uncertainty_score":0.02118069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04502402965561749,"score_gpt":0.3030243027974026,"score_spread":0.2580002731417851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}