{"id":"W2009878875","doi":"10.1172/jci33296","title":"Cholesterol in islet dysfunction and type 2 diabetes","year":2008,"lang":"en","type":"review","venue":"Journal of Clinical Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC; Child and Family Research Institute","keywords":"Endocrinology; Islet; Internal medicine; Type 2 diabetes; ABCA1; Cholesterol; Diabetes mellitus; Context (archaeology); Insulin; Biology; Reverse cholesterol transport; Glucose homeostasis; Homeostasis; Pancreas; Insulin resistance; Medicine; Transporter; Lipoprotein; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005655988,0.0009446843,0.001627879,0.002565228,0.000337109,0.0008923188,0.0007884526,0.00141364,0.002870296],"category_scores_gemma":[0.0006995765,0.0002661821,0.0003632836,0.003145857,0.0005530445,0.001296664,0.0007007335,0.001766078,0.003206608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006424041,"about_ca_system_score_gemma":0.0009453263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258069,"about_ca_topic_score_gemma":0.00203728,"domain_scores_codex":[0.9997811,0.00004124041,0.00003477623,0.00003540303,0.00008969494,0.0000177211],"domain_scores_gemma":[0.9997051,0.0001063507,0.00004707487,0.000009418485,0.0000950508,0.00003684302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009336122,0.00006144901,0.0002837082,0.01070024,0.00006491863,0.0005532482,0.00005785944,0.0002199991,0.001095082,0.002234013,0.05797362,0.9266624],"study_design_scores_gemma":[0.00002319478,0.00007382048,0.001308526,0.003481454,0.00008037116,0.00376018,0.0000670959,0.00005520116,0.0002162877,0.001826261,0.9890897,0.00001788578],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005157981,0.9988906,0.00004581299,0.000203768,0.0002910475,0.000001964557,0.000005814129,0.000004261227,0.0005052296],"genre_scores_gemma":[0.0003732318,0.9984984,0.00009929441,0.0001995195,0.0003412451,0.000002971856,0.00001126152,8.981168e-7,0.0004731175],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002870296,"threshold_uncertainty_score":0.00960207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1506097082789255,"score_gpt":0.4193056563157181,"score_spread":0.2686959480367926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}