{"id":"W2009906860","doi":"10.1016/j.cell.2014.01.047","title":"Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canada Foundation for Innovation; National Center for Research Resources; American Heart Association","keywords":"Biology; Caenorhabditis elegans; Gene; Gene expression; Genetics; Life history; Phenotype; Expression (computer science); Evolutionary biology; Computational biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002629902,0.0004955239,0.0002686485,0.0006854744,0.0003118303,0.0005589693,0.0004139752,0.0003935185,0.00143138],"category_scores_gemma":[0.0002609377,0.0002445891,0.0002122111,0.000251517,0.0004321995,0.0003682316,0.0006642086,0.0005068492,0.0001537845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006833607,"about_ca_system_score_gemma":0.0003724834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401619,"about_ca_topic_score_gemma":0.003370267,"domain_scores_codex":[0.9998018,0.00002357286,0.00001182913,0.00006614804,0.0000612516,0.00003546622],"domain_scores_gemma":[0.9997192,0.00006805863,0.00009378522,0.00003681396,0.00002883755,0.00005324832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001338536,0.00003092866,0.0009997733,0.0000288664,0.00001893372,0.00008927221,0.00001042697,0.0001989963,0.9953739,0.0005320976,0.00005736253,0.002525564],"study_design_scores_gemma":[0.00003248518,0.0002540711,0.05946342,0.00001386482,0.0001218885,0.0003832907,0.00007209076,0.005290732,0.9310859,0.000989587,0.002263378,0.00002937037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938799,0.0008659647,0.002373996,0.0001790853,0.00002174,0.00001293137,0.0003727179,0.0001522151,0.002141502],"genre_scores_gemma":[0.9967495,0.0003679698,0.001312393,0.00007278714,0.00000351815,0.00001316555,0.000195831,0.00002860616,0.001256183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143138,"threshold_uncertainty_score":0.004958212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062127747031153,"score_gpt":0.2019621922962884,"score_spread":0.1913409148259769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}