{"id":"W2009906860","doi":"10.1016/j.cell.2014.01.047","title":"Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canada Foundation for Innovation; National Center for Research Resources; American Heart Association","keywords":"Biology; Caenorhabditis elegans; Gene; Gene expression; Genetics; Life history; Phenotype; Expression (computer science); Evolutionary biology; Computational biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002133904,0.0001745541,0.0002023647,0.00004486268,0.00006643107,0.00002345759,0.0001504418,0.0001668849,0.00002035155],"category_scores_gemma":[0.00009336964,0.0001622482,0.00005814113,0.00002179257,0.000114787,0.000004146696,0.0001032545,0.00008903009,0.000007864232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002371429,"about_ca_system_score_gemma":0.00003899368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003953956,"about_ca_topic_score_gemma":0.000007978644,"domain_scores_codex":[0.9990096,0.0001359421,0.0001701828,0.0003791733,0.00006547399,0.0002396057],"domain_scores_gemma":[0.9994687,0.00002906623,0.00009727824,0.0002330104,0.00004927692,0.0001226788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001099536,0.00002351847,0.001033516,0.00004993335,0.0000202689,3.679134e-7,0.0006471146,0.0001197288,0.9957368,0.00006188138,0.002172799,0.0001230249],"study_design_scores_gemma":[0.0004685903,0.0001849275,0.0005709527,0.00001005831,0.00003430218,0.000006013088,0.0004208122,0.0001442786,0.8619076,0.00003099886,0.1359772,0.0002442917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703019,0.01184575,0.01473204,0.00003132802,0.0007387175,0.0001243656,0.000007634759,0.00002378798,0.002194473],"genre_scores_gemma":[0.9967593,0.0004262164,0.001194399,0.0002437234,0.0004729033,0.000007018339,0.00003587087,0.00002733474,0.000833213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1338293,"threshold_uncertainty_score":0.6616289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062127747031153,"score_gpt":0.2019621922962884,"score_spread":0.1913409148259769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}