{"id":"W2009925295","doi":"10.1021/bi025819z","title":"Extracellular Domains, Transmembrane Segments, and Intracellular Domains Interact To Determine the Cation Selectivity of Na,K- and Gastric H,K-ATPase","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences","keywords":"Ectodomain; Chemistry; ATP hydrolysis; Selectivity; ATPase; Extracellular; Transmembrane domain; Stereochemistry; Protein subunit; H(+)-K(+)-Exchanging ATPase; Transmembrane protein; Mutant; Hydrolysis; Enzyme; Biophysics; Biochemistry; Membrane; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148795,0.0001700151,0.0001387144,0.00003231519,0.00008484197,0.00001851675,0.0001045279,0.0001398593,0.00002727737],"category_scores_gemma":[0.00002580525,0.0001442989,0.00005120885,0.0001171662,0.0001023236,0.000006868147,0.00002789957,0.00008164502,0.000001189049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001348203,"about_ca_system_score_gemma":0.00001444018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001173882,"about_ca_topic_score_gemma":0.000007496024,"domain_scores_codex":[0.9991109,0.00002883283,0.0002230628,0.0003260658,0.0001304845,0.0001807002],"domain_scores_gemma":[0.999486,0.00001490365,0.00008575709,0.0002571514,0.00005391924,0.0001022541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006382025,0.00007603486,0.001481165,0.00009215729,0.00002935562,0.000003568053,0.0001599095,0.00001219614,0.9926566,0.000005793465,0.0001205595,0.00529878],"study_design_scores_gemma":[0.0005220289,0.0001264182,0.002050939,0.00002748271,0.00004046916,0.00005911759,0.00007904522,0.0006339246,0.9950188,0.000009042999,0.00126891,0.0001637984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923009,0.003538265,0.00360328,0.0002195282,0.00003705532,0.0002047434,0.00002529,0.000009332593,0.00006160248],"genre_scores_gemma":[0.9983247,0.0003355776,0.0003894027,0.000038802,0.000121391,0.00001855109,0.0001048152,0.00001706977,0.0006497107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006023777,"threshold_uncertainty_score":0.588434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007906916400076486,"score_gpt":0.2046518437285281,"score_spread":0.1967449273284516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}