{"id":"W2009925295","doi":"10.1021/bi025819z","title":"Extracellular Domains, Transmembrane Segments, and Intracellular Domains Interact To Determine the Cation Selectivity of Na,K- and Gastric H,K-ATPase","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences","keywords":"Ectodomain; Chemistry; ATP hydrolysis; Selectivity; ATPase; Extracellular; Transmembrane domain; Stereochemistry; Protein subunit; H(+)-K(+)-Exchanging ATPase; Transmembrane protein; Mutant; Hydrolysis; Enzyme; Biophysics; Biochemistry; Membrane; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472727,0.0001891677,0.0003489547,0.000156236,0.0000986477,0.0003140793,0.0001835114,0.0003606628,0.0006758299],"category_scores_gemma":[0.000338045,0.0001963795,0.0002376167,0.0001616202,0.0002262326,0.0002752132,0.000355442,0.0003387273,0.0003488577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001562542,"about_ca_system_score_gemma":0.0001107292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002381801,"about_ca_topic_score_gemma":0.0003829977,"domain_scores_codex":[0.9998167,0.00004120815,0.00002343732,0.00002648376,0.00005010373,0.00004208299],"domain_scores_gemma":[0.999774,0.00007980186,0.00005970286,0.00001609691,0.00002431622,0.00004606753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001382263,0.000008591093,0.001348584,0.00001832186,0.000005437918,0.000060089,0.00001247595,0.00005044593,0.9974693,0.00004465423,0.00001335382,0.0008305282],"study_design_scores_gemma":[0.00005233111,0.0001961862,0.04921177,0.000009249718,0.00006558636,0.001465769,0.00008089255,0.002377075,0.9446545,0.0001172537,0.001753906,0.00001542834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984906,0.000405777,0.0007361139,0.00002861361,0.000004841689,0.000004346167,0.00004401592,0.000005693653,0.0002799569],"genre_scores_gemma":[0.9979132,0.0002088649,0.001276004,0.00004212876,0.000004272121,0.000004847979,0.0001458842,0.00000453464,0.0004001409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006758299,"threshold_uncertainty_score":0.002260864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007906916400076486,"score_gpt":0.2046518437285281,"score_spread":0.1967449273284516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}