{"id":"W2009925410","doi":"10.1038/modpathol.3800677","title":"Immunoglobulin V somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome","year":2006,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Calgary Laboratory Services; University of Calgary; University of Alberta","funders":"","keywords":"Somatic hypermutation; Biology; Mantle cell lymphoma; Genotype; Lymphoma; Molecular biology; Germline mutation; Immunoglobulin heavy chain; Antibody; Mutation; B cell; Genetics; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004131833,0.0002453334,0.0003544374,0.0009216637,0.0002974941,0.0005113374,0.0003050495,0.0006996428,0.002861138],"category_scores_gemma":[0.002082836,0.0001460559,0.0002033269,0.0006588503,0.0003518575,0.0004209336,0.0002166079,0.0004309766,0.0003446172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787411,"about_ca_system_score_gemma":0.0001537168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003532943,"about_ca_topic_score_gemma":0.0003703197,"domain_scores_codex":[0.9997624,0.00007283885,0.00002769058,0.00003804365,0.00004399065,0.00005519532],"domain_scores_gemma":[0.9984641,0.0004882848,0.0005303922,0.0001047754,0.0001277312,0.0002846989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001047214,0.0001080422,0.981171,0.00001108857,0.00006112637,0.001107573,0.00006418299,0.0001199597,0.01100202,0.000056047,0.0001283863,0.005123192],"study_design_scores_gemma":[0.00001624139,0.0002819431,0.992251,0.000003934996,0.0000483134,0.005366224,0.00008314168,0.0003965462,0.001255535,0.0001355517,0.0001565183,0.000005054413],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992869,0.0001552911,0.00005928742,0.00004208312,0.000005475042,0.000001380801,0.00003040189,0.000005153219,0.0004139062],"genre_scores_gemma":[0.9997695,0.00002792089,0.00003454181,0.00001239398,0.00001414309,0.000001332832,0.00004235212,0.000002028594,0.00009586086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002861138,"threshold_uncertainty_score":0.009571493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01659824985177889,"score_gpt":0.2784850049740279,"score_spread":0.2618867551222491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}