{"id":"W2009925410","doi":"10.1038/modpathol.3800677","title":"Immunoglobulin V somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome","year":2006,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Calgary Laboratory Services; University of Calgary; University of Alberta","funders":"","keywords":"Somatic hypermutation; Biology; Mantle cell lymphoma; Genotype; Lymphoma; Molecular biology; Germline mutation; Immunoglobulin heavy chain; Antibody; Mutation; B cell; Genetics; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809496,0.0002073455,0.0005155209,0.0001132733,0.00004394587,0.00001274682,0.00006422776,0.0002092359,0.00004667425],"category_scores_gemma":[0.00001964831,0.0001512973,0.00009253016,0.0001198846,0.0001009108,0.00004912794,0.00003078478,0.0001044442,0.0003342462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001578663,"about_ca_system_score_gemma":0.00007517599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001862484,"about_ca_topic_score_gemma":0.00009440424,"domain_scores_codex":[0.9984019,0.0001147946,0.0006223134,0.0003930138,0.0001484011,0.0003195978],"domain_scores_gemma":[0.9993007,0.0001343329,0.0001422172,0.000314299,0.00005104721,0.00005742289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002512934,0.002020296,0.9846586,0.00003473881,0.00003126837,0.003804879,0.0001790942,0.0001778283,0.0009691585,0.0000296462,0.00007279202,0.007770386],"study_design_scores_gemma":[0.01234413,0.0005552226,0.979941,0.00003665391,0.000182772,0.0006589274,0.00002853786,0.003979201,0.001111257,0.0009392449,0.00005822917,0.0001648752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99612,0.0006841267,0.0005741718,0.0005881612,0.0001384811,0.0004079674,0.00000872959,0.00006786273,0.001410511],"genre_scores_gemma":[0.9964268,0.00002550815,0.002125606,0.0006676436,0.00005880581,0.00006829193,0.0001782141,0.00003393931,0.0004151462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01209284,"threshold_uncertainty_score":0.6169727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01659824985177889,"score_gpt":0.2784850049740279,"score_spread":0.2618867551222491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}