{"id":"W2009935784","doi":"10.1074/jbc.m110.182881","title":"CK2 Phosphorylation of an Acidic Ser/Thr Di-isoleucine Motif in the Na+/H+ Exchanger NHE5 Isoform Promotes Association with β-Arrestin2 and Endocytosis","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Hospital for Sick Children; McGill University","funders":"U.S. Public Health Service","keywords":"Internalization; Phosphorylation; G protein-coupled receptor; Endocytic cycle; Biochemistry; Threonine; Kinase; Serine; Cell biology; Endocytosis; Protein subunit; Isoleucine; Casein kinase 2; Chemistry; Signal transducing adaptor protein; Biology; Protein kinase A; Amino acid; Receptor; Leucine; Cyclin-dependent kinase 2; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008042221,0.00021083,0.0001710614,0.00007595639,0.0001048528,0.0001894773,0.0001066336,0.0001231676,0.0009678137],"category_scores_gemma":[0.00006611283,0.0000928903,0.0001920974,0.00007057228,0.0001086938,0.00009758402,0.0001397681,0.0002619619,0.0002732377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570827,"about_ca_system_score_gemma":0.0001321553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007003736,"about_ca_topic_score_gemma":0.001199434,"domain_scores_codex":[0.9999307,0.00001064895,0.000007924035,0.00001558629,0.00001418349,0.0000209142],"domain_scores_gemma":[0.999954,0.000004974258,0.0000176759,0.000003908199,0.000003910674,0.00001560161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001268692,0.00001042918,0.0001778389,0.00001402335,0.000004849825,0.00002976947,0.000004100391,0.0000421157,0.999276,0.00004518648,0.00001746671,0.0002513159],"study_design_scores_gemma":[0.00002101254,0.0001238566,0.008845817,0.000003933287,0.00001505417,0.0002671687,0.00001790397,0.001383055,0.9877187,0.00001982371,0.001579293,0.000004366234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984384,0.0004121436,0.0004690105,0.00002440672,0.000009941848,0.000006617496,0.00007996911,0.00001321525,0.0005462719],"genre_scores_gemma":[0.9974783,0.000289302,0.0005606458,0.0000287214,0.000005678093,0.000008761143,0.0003024737,0.000009013479,0.001316984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009678137,"threshold_uncertainty_score":0.003237605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234464954670168,"score_gpt":0.22947583668447,"score_spread":0.2060293412174532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}