{"id":"W2009940306","doi":"10.1073/pnas.0705659105","title":"Structural basis for the high <i>all-trans</i> -retinaldehyde reductase activity of the tumor marker AKR1B10","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Barcelona Supercomputing Center; Queen's University; Generalitat de Catalunya","keywords":"Retinaldehyde; Aldose reductase; Aldo-keto reductase; Retinoic acid; Biochemistry; Reductase; In vivo; Aldehyde Reductase; Biology; Chemistry; Enzyme; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001255681,0.00009813671,0.0001117663,0.00003374714,0.000212781,0.000009620716,0.000793573,0.00006666618,0.000007432497],"category_scores_gemma":[0.0004117154,0.00004763688,0.0001442993,0.0002890225,0.0009836665,0.00001978653,0.0001332531,0.000109716,6.525835e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001131966,"about_ca_system_score_gemma":0.00005249296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001408678,"about_ca_topic_score_gemma":4.88793e-7,"domain_scores_codex":[0.9988145,0.000007316077,0.000231254,0.0002047103,0.0005726307,0.0001695903],"domain_scores_gemma":[0.9992467,0.00009704476,0.0003777777,0.00002298054,0.0002303763,0.00002510139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001088866,0.00002167105,0.001251553,0.00004036194,0.00003996967,3.104619e-9,0.00003333934,0.00002254679,0.9940189,0.003088726,0.0009636585,0.0004103517],"study_design_scores_gemma":[0.0001531325,0.00004961602,0.05410693,0.00002458785,0.00003412139,0.00001320389,0.00008977557,0.00006954859,0.9407089,0.003416892,0.001273633,0.00005967679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994337,0.0001931142,0.000004881832,0.004538083,0.00004954801,0.0002661013,0.00008061023,0.000002013345,0.0005287155],"genre_scores_gemma":[0.9988062,0.0000328849,0.0005648673,0.0003132393,0.0001644273,0.000007994967,5.259432e-7,0.000004722576,0.000105084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05331005,"threshold_uncertainty_score":0.362436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02325566091655679,"score_gpt":0.2963276836708058,"score_spread":0.273072022754249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}