{"id":"W2009948563","doi":"10.1086/424528","title":"Transmission-Ratio Distortion and Allele Sharing in Affected Sib Pairs: A New Linkage Statistic with Reduced Bias, with Application to Chromosome 6q25.3","year":2004,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université du Québec à Chicoutimi; McGill University and Génome Québec Innovation Centre; McGill Genome Centre; Université de Montréal; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Mitacs; Health Research Foundation; Burroughs Wellcome Fund","keywords":"Pedigree chart; Genetics; Linkage (software); Allele; Biology; Statistic; Test statistic; Trait; Sibling; Genotype; Genetic linkage; Distortion (music); Statistics; Statistical hypothesis testing; Mathematics; Computer science; Psychology; Gene; Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03510976,0.001015844,0.002588992,0.006426681,0.0006516264,0.001486964,0.003636808,0.001524441,0.003250356],"category_scores_gemma":[0.1282481,0.000629999,0.001845695,0.005779416,0.001929494,0.001725251,0.002123581,0.001700246,0.0004562681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008768728,"about_ca_system_score_gemma":0.001465383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00269976,"about_ca_topic_score_gemma":0.002995787,"domain_scores_codex":[0.9710688,0.02042674,0.001534581,0.002954076,0.003707944,0.0003078216],"domain_scores_gemma":[0.828516,0.1504163,0.006867534,0.009024302,0.004330351,0.0008454493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.004518976,0.0004355082,0.3223773,0.001004159,0.006457775,0.001617227,0.001102848,0.08757663,0.008187484,0.05009604,0.007099821,0.5095263],"study_design_scores_gemma":[0.001365901,0.002037938,0.168896,0.0001505864,0.002111437,0.00773214,0.0004206566,0.740276,0.006333643,0.06109093,0.008956459,0.0006281721],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1547722,0.001388945,0.8381094,0.0005795917,0.0001441862,0.0003379863,0.001679155,0.001513018,0.001475489],"genre_scores_gemma":[0.5046441,0.0006557743,0.4900766,0.0001652248,0.00039327,0.0005923799,0.001535252,0.0004659814,0.001471397],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03510976,"threshold_uncertainty_score":0.1856804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257147391903064,"score_gpt":0.2681198427281045,"score_spread":0.2555483688090738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}