{"id":"W2009959558","doi":"10.1523/jneurosci.0917-10.2010","title":"Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Fondazione Cariplo; European Commission; CHDI Foundation","keywords":"Apolipoprotein E; Cholesterol; Huntington's disease; Biology; Internal medicine; Endocrinology; Cell biology; Genetically modified mouse; Transgene; Biochemistry; Gene; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001250144,0.0006119328,0.0004078378,0.0008944575,0.0002860454,0.0002817779,0.0001566912,0.0003366468,0.001560956],"category_scores_gemma":[0.0001226225,0.0002437657,0.0002187879,0.0003268668,0.0004017835,0.0002044198,0.0003883437,0.0005069149,0.0004757759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001716066,"about_ca_system_score_gemma":0.0002310341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007264626,"about_ca_topic_score_gemma":0.001773594,"domain_scores_codex":[0.99981,0.00001471794,0.00002568748,0.00005829859,0.00006852621,0.00002266998],"domain_scores_gemma":[0.9997713,0.000009975172,0.0001047844,0.00002411478,0.00002691366,0.00006296854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00028243,0.00004654243,0.001531441,0.00007701849,0.00003066698,0.0008647481,0.00005001309,0.00003063298,0.9939447,0.0001790052,0.0001300875,0.00283267],"study_design_scores_gemma":[0.0001057615,0.001078248,0.1304763,0.00007746242,0.0003027862,0.0227246,0.0002593166,0.0006997206,0.8318959,0.0009302599,0.0114168,0.00003296036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988287,0.003320415,0.003989424,0.0001855218,0.00007813401,0.000072866,0.00108281,0.0003562306,0.002627532],"genre_scores_gemma":[0.9839051,0.003206902,0.003926776,0.0001415169,0.00003057428,0.0001206587,0.00159423,0.0001045144,0.006969653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001560956,"threshold_uncertainty_score":0.005221903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03165390588103956,"score_gpt":0.2899397888196871,"score_spread":0.2582858829386476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}