{"id":"W2009966467","doi":"10.1038/nature13492","title":"Coordinated regulation of protein synthesis and degradation by mTORC1","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":360,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"mTORC1; Proteasome; Cell biology; Protein degradation; Catabolism; NRF1; Biology; Transcription factor; Anabolism; Protein biosynthesis; RHEB; Biochemistry; Chemistry; PI3K/AKT/mTOR pathway; Signal transduction; Gene; Metabolism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000460352,0.0005617437,0.0007336728,0.0006737175,0.0004751936,0.001482289,0.0003737131,0.0004375663,0.00113554],"category_scores_gemma":[0.0003549776,0.0003970393,0.0003711871,0.0003392033,0.0003771157,0.000810636,0.0008366143,0.0006086143,0.0007114809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001238151,"about_ca_system_score_gemma":0.00056602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005573077,"about_ca_topic_score_gemma":0.001655494,"domain_scores_codex":[0.999564,0.00005653856,0.00004525221,0.0001367941,0.0001041544,0.00009327503],"domain_scores_gemma":[0.999713,0.00003013907,0.00007091859,0.00002709033,0.0000960519,0.00006277108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009118132,0.00005082924,0.001456981,0.000219814,0.00005313429,0.0002072658,0.00006417561,0.0006206183,0.974291,0.00287147,0.001874439,0.01737849],"study_design_scores_gemma":[0.0001004426,0.0003707177,0.0657834,0.00007536732,0.00009819595,0.0009668854,0.0002479847,0.01015701,0.8942806,0.003703082,0.02414448,0.00007188549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9080433,0.05128025,0.01952053,0.002613145,0.0008535659,0.0001188635,0.001785697,0.001016439,0.01476823],"genre_scores_gemma":[0.982012,0.005286497,0.00599955,0.0002360834,0.0001309104,0.00008089882,0.001070638,0.0001308787,0.005052593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482289,"threshold_uncertainty_score":0.008983493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002248600350296333,"score_gpt":0.2065567750427182,"score_spread":0.2043081746924219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}