{"id":"W2010001537","doi":"10.1007/s12308-012-0155-7","title":"Acute myeloid leukemia with promyelocytic morphology lacking RARA rearrangement and with double minutes, MYC deletion and 2 cell lines with amplification of MYC region: case report and literature review","year":2012,"lang":"en","type":"article","venue":"Journal of Hematopathology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Acute promyelocytic leukemia; Chromosomal translocation; Biology; Karyotype; Monosomy; Myeloid; Gene rearrangement; Myeloid leukemia; Fusion transcript; Cancer research; Hematology; Cytogenetics; Gene duplication; Fusion gene; Chromosomal rearrangement; Molecular biology; Genetics; Chromosome; Cell culture; Gene; Immunology; Retinoic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004602123,0.0001919372,0.0004033212,0.00006984286,0.00006419936,0.00001996705,0.00006471128,0.0001559161,0.000001470548],"category_scores_gemma":[0.00002405571,0.0001209684,0.000026863,0.0000974494,0.0002332087,0.00003402953,0.00004444355,0.0001852974,9.965807e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002125651,"about_ca_system_score_gemma":0.0001300938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002925876,"about_ca_topic_score_gemma":0.000004488497,"domain_scores_codex":[0.9989323,0.00007883183,0.0004175675,0.0002554502,0.0001228481,0.0001930087],"domain_scores_gemma":[0.9985281,0.00001644448,0.0007596567,0.0002376578,0.0003556879,0.0001024256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.003603407,0.0002072394,0.06405797,0.008242112,0.0003093976,0.06868529,0.001606087,0.00001410303,0.8502673,0.0001377179,0.001051826,0.001817539],"study_design_scores_gemma":[0.001646779,0.001382448,0.0007930283,0.001198265,0.0003561923,0.8535219,0.0001803109,0.000002457312,0.1393647,0.00001418813,0.001362693,0.0001770213],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9068316,0.09029353,0.002301694,0.0002203107,0.00002888813,0.0002388411,0.000001934777,0.000003432611,0.00007975726],"genre_scores_gemma":[0.9620956,0.02902362,0.008377203,0.0001268554,0.0001328238,0.0000181323,0.00002766409,0.00002196206,0.0001762069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7848366,"threshold_uncertainty_score":0.4932947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009838727008629415,"score_gpt":0.2412377659972517,"score_spread":0.2313990389886223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}