{"id":"W2010013932","doi":"10.1155/2012/823193","title":"Targeting the ACE2 and Apelin Pathways Are Novel Therapies for Heart Failure: Opportunities and Challenges","year":2012,"lang":"en","type":"article","venue":"Cardiology Research and Practice","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Heart and Stroke Foundation of Canada","keywords":"Apelin; Angiotensin-converting enzyme 2; Heart failure; Medicine; Renin–angiotensin system; Angiotensin II; Internal medicine; Knockout mouse; Homeostasis; Regulator; Endocrinology; Blood pressure; Endogeny; Pharmacology; Receptor; Biology; Coronavirus disease 2019 (COVID-19); Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01102479,0.0001423906,0.0003709476,0.0001197646,0.0005064833,0.00005047146,0.00009233583,0.0002783173,0.00001841396],"category_scores_gemma":[0.01388689,0.00008668606,0.00003847125,0.0001016216,0.001646279,0.0002683733,0.000258392,0.0009637729,0.000009843022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002228687,"about_ca_system_score_gemma":0.0001409714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001377486,"about_ca_topic_score_gemma":0.000002050556,"domain_scores_codex":[0.9974094,0.0008964275,0.0001865905,0.0003097397,0.0004263739,0.0007714616],"domain_scores_gemma":[0.9846821,0.01402626,0.00005631919,0.0002338049,0.0005382374,0.00046328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02219567,0.001346799,0.04328617,0.005781162,0.007101732,0.0006002148,0.04595705,0.000001474481,0.227823,0.07215524,0.2500536,0.3236979],"study_design_scores_gemma":[0.001191777,0.0008524439,0.01401561,0.00006355065,0.00007184737,0.001312735,0.0692218,0.00004833227,0.0000718671,0.0003834948,0.9126487,0.0001178268],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1822025,0.3701329,0.0003046961,0.4435856,0.0001290209,0.001448969,0.00004815475,0.00004776093,0.002100365],"genre_scores_gemma":[0.8476011,0.1483268,0.001626992,0.000972621,0.0009560161,0.0001604705,0.00001904237,0.00002777986,0.0003091056],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6653987,"threshold_uncertainty_score":0.9944196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3896871600590871,"score_gpt":0.4311899811429361,"score_spread":0.04150282108384901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}