{"id":"W2010052397","doi":"10.1158/1538-7445.am2014-4915","title":"Abstract 4915: High degree of G2/M arrest induced by Polo-like kinase 1 (PLK1) inhibition is associated with radiosensitization","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"PLK1; Cancer research; Clonogenic assay; Propidium iodide; Cell cycle; Cancer; Kinase; Cancer cell; Radiosensitizer; Colorectal cancer; Cell culture; Cell cycle checkpoint; Medicine; Biology; Chemistry; Radiation therapy; Apoptosis; Programmed cell death; Cell biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001028875,0.0004537812,0.0004399708,0.0003219994,0.0001891827,0.0002398435,0.0002173019,0.0003343379,0.005912532],"category_scores_gemma":[0.00009145509,0.0001669204,0.0002759739,0.0002556576,0.0001626799,0.0001290606,0.000202933,0.0006530776,0.001215466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562565,"about_ca_system_score_gemma":0.0001595946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004354944,"about_ca_topic_score_gemma":0.0003915096,"domain_scores_codex":[0.9998815,0.00001551591,0.0000164268,0.00002531329,0.00002700559,0.00003409278],"domain_scores_gemma":[0.9998934,0.0000194093,0.00003056769,0.00001349594,0.000009321652,0.00003386089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002714942,0.00004523377,0.0001690013,0.00005656588,0.000008640816,0.00007816261,0.000005769935,0.00003322541,0.9981147,0.00004869741,0.0001422796,0.001026114],"study_design_scores_gemma":[0.00002125138,0.0006261486,0.006149315,0.000006820124,0.00001261562,0.0002991176,0.000009292207,0.0002868203,0.9907135,0.00003249943,0.001839964,0.000002597475],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849455,0.006278249,0.002139847,0.0002319692,0.0001379042,0.00007674758,0.001784584,0.0002651011,0.004139886],"genre_scores_gemma":[0.9899269,0.001488299,0.0009283498,0.000129828,0.00002503017,0.00007902002,0.002347666,0.00004417905,0.005030737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005912532,"threshold_uncertainty_score":0.01977944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03552680497428885,"score_gpt":0.3127791576482474,"score_spread":0.2772523526739585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}