{"id":"W2010053743","doi":"10.1111/j.1365-2958.2008.06365.x","title":"Mycothiol biosynthesis is essential for ethionamide susceptibility in <i>Mycobacterium tuberculosis</i>","year":2008,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Welch Foundation; British Columbia Lung Association; Howard Hughes Medical Institute","keywords":"Ethionamide; Biology; Mycobacterium tuberculosis; Mutant; DNA ligase; Genetics; Microbiology; Isoniazid; Gene; Tuberculosis; Streptomycin; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006957721,0.0003062741,0.0008261492,0.0002833786,0.0001101173,0.000006084023,0.0002086488,0.000584616,0.0003579071],"category_scores_gemma":[0.001323986,0.0002731751,0.0004201205,0.0002689208,0.0004717809,0.0000457762,0.0001248622,0.0004639393,0.0001473874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001666649,"about_ca_system_score_gemma":0.000199568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002679971,"about_ca_topic_score_gemma":0.0001170914,"domain_scores_codex":[0.9970524,0.0004516014,0.0006213519,0.0008366235,0.00008738531,0.0009505806],"domain_scores_gemma":[0.9983934,0.0004918068,0.00008873874,0.0006263636,0.0001828546,0.0002168836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005866743,0.0002740712,0.03157935,0.0001186692,0.0001434977,0.0001655585,0.0001431101,0.000005013661,0.9565772,0.0001181852,0.009982321,0.0003063454],"study_design_scores_gemma":[0.002955764,0.0008679735,0.03666143,0.0000967678,0.0001176425,0.001944239,0.0000497503,0.0002005064,0.8967764,0.0002400001,0.05955666,0.0005328542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843748,0.0007800257,0.0009925304,0.01201502,0.0001922025,0.0009867777,0.0001750096,0.00006477739,0.0004188956],"genre_scores_gemma":[0.9866038,0.000475717,0.002470746,0.009657519,0.0001213268,0.0001366788,0.0003145533,0.00004520405,0.0001744717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0598008,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01862373762078593,"score_gpt":0.297423174230705,"score_spread":0.278799436609919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}