{"id":"W2010053743","doi":"10.1111/j.1365-2958.2008.06365.x","title":"Mycothiol biosynthesis is essential for ethionamide susceptibility in <i>Mycobacterium tuberculosis</i>","year":2008,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Welch Foundation; British Columbia Lung Association; Howard Hughes Medical Institute","keywords":"Ethionamide; Biology; Mycobacterium tuberculosis; Mutant; DNA ligase; Genetics; Microbiology; Isoniazid; Gene; Tuberculosis; Streptomycin; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009960989,0.0002590555,0.0002091807,0.0002157103,0.0001477763,0.0003599612,0.0001674751,0.0002646362,0.0005904082],"category_scores_gemma":[0.0003270286,0.0001714867,0.0001655604,0.0001489309,0.0002144477,0.0001259641,0.0001970099,0.0002756973,0.0002656517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936307,"about_ca_system_score_gemma":0.000168695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007029772,"about_ca_topic_score_gemma":0.0008155999,"domain_scores_codex":[0.9998596,0.00002634684,0.00001848149,0.00002272249,0.00003852828,0.00003433583],"domain_scores_gemma":[0.9997491,0.00005114288,0.0001033157,0.00002834716,0.00002816285,0.00003991385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005901802,0.00001100368,0.001432557,0.000009675715,0.000003106953,0.0001300364,0.0000122369,0.00002286851,0.9976714,0.00002359041,0.00000845397,0.0006160864],"study_design_scores_gemma":[0.00003151919,0.0003319661,0.05988202,0.00001504243,0.00003904813,0.004667171,0.0001015619,0.0007605369,0.9324931,0.00009179116,0.001573261,0.00001296066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989512,0.0002286266,0.0004636964,0.00002643011,0.000003012281,0.000003858642,0.00008133335,0.00001678769,0.0002251085],"genre_scores_gemma":[0.9990596,0.0001307719,0.0004583647,0.00001112734,0.000002384574,0.000003373952,0.0001630564,0.00001043125,0.0001608978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007029772,"threshold_uncertainty_score":0.001975119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01862373762078593,"score_gpt":0.297423174230705,"score_spread":0.278799436609919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}