{"id":"W2010082382","doi":"10.1139/cjc-2012-0537","title":"Modification of the anticancer drug tamoxifen to avoid CYP2D6 polymorphism","year":2013,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Göteborgs Universitet","keywords":"Prodrug; Chemistry; CYP2D6; Tamoxifen; Drug; CYP3A; Adduct; Stereochemistry; Pharmacology; Cytochrome P450; Breast cancer; Combinatorial chemistry; Biochemistry; Enzyme; Cancer; Genetics; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037578,0.0001973944,0.0002238949,0.0001086594,0.0001518525,0.0001524359,0.0003294582,0.0003608734,0.002473468],"category_scores_gemma":[0.0003125398,0.00009730516,0.0003561392,0.000125635,0.0001411189,0.0001694545,0.0001946323,0.0002643308,0.000457378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001482071,"about_ca_system_score_gemma":0.0001633743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006262011,"about_ca_topic_score_gemma":0.000710275,"domain_scores_codex":[0.9999198,0.00001929252,0.000003309449,0.00001561504,0.0000287895,0.00001312245],"domain_scores_gemma":[0.9999578,0.00001044778,0.00001332621,0.000009047516,0.000006306927,0.000003042417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001018766,0.0002386709,0.005903897,0.0008291629,0.0002155942,0.001422318,0.0001450825,0.06420088,0.8187609,0.02798939,0.001733841,0.07754142],"study_design_scores_gemma":[0.0004467422,0.005595812,0.008720594,0.00006177062,0.0003273043,0.002640103,0.0001225148,0.1160002,0.7911043,0.01304273,0.06184484,0.00009306233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.932056,0.005076676,0.04825531,0.0005136285,0.0001160423,0.0001339567,0.0005486329,0.0001905002,0.01310925],"genre_scores_gemma":[0.9858962,0.001436211,0.01037161,0.00008559896,0.00001362672,0.00003878937,0.0002480488,0.00002282276,0.001886972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002473468,"threshold_uncertainty_score":0.008274615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05366901459742366,"score_gpt":0.354078313607545,"score_spread":0.3004092990101213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}