{"id":"W2010094069","doi":"10.1016/j.vaccine.2005.08.076","title":"DNA vaccines in sheep: CTLA-4 mediated targeting and CpG motifs enhance immunogenicity in a DNA prime/protein boost strategy","year":2005,"lang":"en","type":"article","venue":"Vaccine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Australian Research Council; Monash University; Australian Government","keywords":"Immune system; Biology; Immunogenicity; Immunology; DNA vaccination; Antigen; Adjuvant; CpG site; Cytotoxic T cell; Vaccination; Antibody; DNA methylation; Immunization; Genetics; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003889485,0.0004196825,0.0003966291,0.0003657814,0.00009131627,0.0003139772,0.0003124356,0.0007781872,0.001308065],"category_scores_gemma":[0.000305408,0.0002125888,0.0001821461,0.0001260859,0.0003150158,0.0004343398,0.0002410307,0.00104185,0.0005558056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002406404,"about_ca_system_score_gemma":0.0002238518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002390884,"about_ca_topic_score_gemma":0.0002996758,"domain_scores_codex":[0.9998959,0.00003267945,0.000006721403,0.00001968806,0.0000194787,0.00002563594],"domain_scores_gemma":[0.9998801,0.00003759805,0.00002830182,0.00001346057,0.00001678526,0.00002377946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004876722,0.00007997185,0.0001453878,0.00006950521,0.000006722419,0.00005621156,0.00001494513,0.0002660457,0.9922334,0.0004253224,0.00008610023,0.006128756],"study_design_scores_gemma":[0.0001423348,0.002143019,0.0005629463,0.00001651322,0.00004484943,0.0003999304,0.0000161929,0.0018809,0.9918733,0.0004249303,0.002489121,0.000005998796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594947,0.003990946,0.0323489,0.0007451142,0.0002148683,0.000103577,0.0001318353,0.0003353463,0.002634656],"genre_scores_gemma":[0.9818466,0.0007762746,0.01391954,0.000117034,0.00004478195,0.00005825664,0.0001065902,0.00003135884,0.003099514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308065,"threshold_uncertainty_score":0.004375875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005450381727542376,"score_gpt":0.2251219923633256,"score_spread":0.2196716106357832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}