{"id":"W2010095686","doi":"10.1074/jbc.m608234200","title":"Neutralization of Acidic Residues in Helix II Stabilizes the Folded Conformation of Acyl Carrier Protein and Variably Alters Its Function with Different Enzymes","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Acyl carrier protein; Enzyme; Chemistry; Helix (gastropod); Biophysics; Neutralization; Function (biology); Biochemistry; Stereochemistry; Biology; Cell biology; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001653911,0.0001008285,0.0001814755,0.00001777133,0.00003196545,0.000005503592,0.00009149038,0.0001514882,0.000007641246],"category_scores_gemma":[0.00008422389,0.00005328923,0.0000447358,0.00005910604,0.0001396849,0.000009542766,0.0000328089,0.00009691644,8.699613e-9],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001091538,"about_ca_system_score_gemma":0.00004140688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001050655,"about_ca_topic_score_gemma":0.000008224799,"domain_scores_codex":[0.999293,0.00004341112,0.0003697354,0.00009364936,0.0001088961,0.00009130158],"domain_scores_gemma":[0.9993104,0.0000150819,0.0004110494,0.00009151021,0.000143129,0.00002884287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005935795,0.00003630023,0.00876665,0.00007610693,0.00002312139,6.550318e-7,0.00003433857,0.0002446985,0.9899869,0.0001075771,0.00001510748,0.000114944],"study_design_scores_gemma":[0.0006323651,0.0005791457,0.01764131,0.00004748926,0.00001805068,0.00002181224,0.0001578477,0.00003845827,0.9800878,0.0006470969,0.00006230282,0.00006629639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977858,0.001087645,0.0008017122,0.00008228514,0.00001565835,0.0001339614,0.00001510387,0.000001741926,0.00007611509],"genre_scores_gemma":[0.9996518,0.0001213141,0.0000807996,0.00001907776,0.00006192731,0.000005117086,0.00003446245,0.000003661393,0.00002186682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009899097,"threshold_uncertainty_score":0.2173072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006545283908994029,"score_gpt":0.2054863665624727,"score_spread":0.1989410826534787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}