{"id":"W2010110230","doi":"10.1038/nchembio.301","title":"Carbon metabolism–mediated myogenic differentiation","year":2010,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Howard Hughes Medical Institute","keywords":"C2C12; Cell biology; Cellular differentiation; Biochemistry; Pentose phosphate pathway; Myocyte; Enzyme; Gene knockdown; Biology; Metabolism; Chemistry; Myogenesis; Glycolysis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184509,0.0004811452,0.000176227,0.0004637805,0.0002605762,0.0004214875,0.0003801765,0.0004076429,0.002966987],"category_scores_gemma":[0.0001004553,0.0002350668,0.0003058813,0.0003012906,0.000335904,0.0002548783,0.0005099295,0.0009311781,0.0007262629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007092106,"about_ca_system_score_gemma":0.0005026449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001546552,"about_ca_topic_score_gemma":0.003717911,"domain_scores_codex":[0.999848,0.00002037799,0.00001390101,0.00003306765,0.00004599244,0.00003854683],"domain_scores_gemma":[0.9998995,0.00002190561,0.00001718778,0.00001725918,0.00001402626,0.00003009446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001994231,0.00002425714,0.00007951857,0.00007763445,0.000007625091,0.00006458941,0.00001137311,0.0001084495,0.992516,0.001409865,0.0002322217,0.005269161],"study_design_scores_gemma":[0.00002067902,0.00007717363,0.001586666,0.00001152017,0.000008730523,0.00007264297,0.00001164997,0.0002899554,0.9905778,0.0001412254,0.007197876,0.000004105391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8657228,0.02597031,0.03036206,0.002339997,0.001264726,0.0003316956,0.00391377,0.0006731669,0.0694214],"genre_scores_gemma":[0.9521993,0.005896423,0.008102732,0.0003768368,0.00006644214,0.00009236021,0.001180147,0.0000896924,0.03199619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002966987,"threshold_uncertainty_score":0.009925604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003457628608623163,"score_gpt":0.2622004242587758,"score_spread":0.2587427956501526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}