{"id":"W2010110230","doi":"10.1038/nchembio.301","title":"Carbon metabolism–mediated myogenic differentiation","year":2010,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Howard Hughes Medical Institute","keywords":"C2C12; Cell biology; Cellular differentiation; Biochemistry; Pentose phosphate pathway; Myocyte; Enzyme; Gene knockdown; Biology; Metabolism; Chemistry; Myogenesis; Glycolysis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001461475,0.0001844666,0.0001944975,0.00006775259,0.00003941155,0.00001017952,0.0003165436,0.001572397,0.00007712864],"category_scores_gemma":[0.0009146493,0.0001588837,0.0001134946,0.0001473748,0.0002099356,0.000001777088,0.000160337,0.001170445,0.00003009159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001505924,"about_ca_system_score_gemma":0.00007152163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001274426,"about_ca_topic_score_gemma":0.0000305935,"domain_scores_codex":[0.9987346,0.00006509619,0.000195958,0.0004973093,0.0001289112,0.0003781485],"domain_scores_gemma":[0.9991935,0.00004022061,0.00006151077,0.0004163315,0.0001406294,0.0001477891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006626912,0.00005149779,0.0007131305,0.000004822994,0.00003449673,0.000001272017,0.000006814319,6.167623e-8,0.9969991,0.0002079656,0.001128559,0.0007860261],"study_design_scores_gemma":[0.0004483769,0.0000378372,0.0006280596,0.000001350236,0.00001160605,0.00001338945,0.000002220675,0.00002738006,0.9305423,0.0001020498,0.06801411,0.0001712859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996299,0.0009821526,0.0000157729,0.0003415771,0.0007387461,0.0001410004,0.00004018717,0.00003356607,0.00140801],"genre_scores_gemma":[0.9968633,0.00004664118,0.0002366576,0.0002844665,0.001046132,0.00003048151,0.001272643,0.00002596704,0.0001937208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06688555,"threshold_uncertainty_score":0.9997238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003457628608623163,"score_gpt":0.2622004242587758,"score_spread":0.2587427956501526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}