{"id":"W2010122622","doi":"10.1016/j.cell.2011.08.023","title":"An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming","year":2011,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":394,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Howard Hughes Medical Institute","keywords":"Biology; Reprogramming; Homeobox protein NANOG; Induced pluripotent stem cell; Embryonic stem cell; Transcription factor; Cell biology; Alternative splicing; Rex1; Cellular differentiation; Somatic cell; Nanog Homeobox Protein; Cell potency; Stem cell; RNA splicing; Regulation of gene expression; Genetics; Gene isoform; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003084121,0.0002030759,0.0001619137,0.00006523706,0.0001219763,0.00004506208,0.0003286672,0.0001476577,0.00002676788],"category_scores_gemma":[0.000005662909,0.0001935671,0.00006302766,0.00009057442,0.00009701589,0.00001198149,0.0002150381,0.0001508066,0.00003337996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001596358,"about_ca_system_score_gemma":0.00004668661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001336667,"about_ca_topic_score_gemma":0.00001965903,"domain_scores_codex":[0.9984063,0.0000920379,0.0001980098,0.0006802765,0.0001761687,0.0004472221],"domain_scores_gemma":[0.9989577,0.00001065821,0.0001016097,0.0006356246,0.00009093613,0.0002034558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006020297,0.0001270792,0.00207779,0.00007727816,0.00001832946,0.00002800926,0.0004741611,0.00001377452,0.992379,0.00001302986,0.00009665415,0.004634712],"study_design_scores_gemma":[0.0004714211,0.0004701809,0.001358956,0.00001639345,0.00001593494,0.0000174899,0.0003952391,0.0004625338,0.9941936,0.00009328435,0.002257268,0.0002477143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882465,0.001772368,0.0005716062,0.00001821091,0.00009229336,0.0002746202,0.000004486484,0.0000276117,0.008992292],"genre_scores_gemma":[0.991977,0.0004115045,0.001443069,0.00003795564,0.0001262132,0.00001930159,0.00002888527,0.00004323215,0.005912886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004386997,"threshold_uncertainty_score":0.7893435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975692129787041,"score_gpt":0.2519614517897785,"score_spread":0.2322045304919081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}