{"id":"W2010122622","doi":"10.1016/j.cell.2011.08.023","title":"An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming","year":2011,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":394,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Howard Hughes Medical Institute","keywords":"Biology; Reprogramming; Homeobox protein NANOG; Induced pluripotent stem cell; Embryonic stem cell; Transcription factor; Cell biology; Alternative splicing; Rex1; Cellular differentiation; Somatic cell; Nanog Homeobox Protein; Cell potency; Stem cell; RNA splicing; Regulation of gene expression; Genetics; Gene isoform; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004100197,0.0003385391,0.0002732148,0.0002717683,0.0003089533,0.000738972,0.0003208352,0.000469437,0.001806042],"category_scores_gemma":[0.0002908,0.0002250536,0.0004497174,0.000176657,0.0003820793,0.0005026758,0.0003059031,0.0008302456,0.0009423133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002991913,"about_ca_system_score_gemma":0.0001961507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001368692,"about_ca_topic_score_gemma":0.0003111455,"domain_scores_codex":[0.9997287,0.00004494816,0.00002606205,0.00008458216,0.00007431812,0.00004124046],"domain_scores_gemma":[0.9997937,0.00006155139,0.00004683963,0.00003390142,0.00002904802,0.00003496943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006457318,0.00001102327,0.0002332646,0.00001673005,0.000005540057,0.0001828648,0.00002037559,0.00007109258,0.9932219,0.002540157,0.0001241389,0.003508315],"study_design_scores_gemma":[0.00002261525,0.0001097396,0.001995487,0.000006845056,0.00003002853,0.00107484,0.00003298716,0.00179615,0.984736,0.001623594,0.008559376,0.00001232859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9233991,0.003594569,0.05911302,0.000877354,0.0007085166,0.0000704296,0.0006156242,0.0007744793,0.0108468],"genre_scores_gemma":[0.9812211,0.00123212,0.01035211,0.0002666362,0.0001274139,0.0000273551,0.0006344824,0.0001976899,0.005941119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001806042,"threshold_uncertainty_score":0.006041825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975692129787041,"score_gpt":0.2519614517897785,"score_spread":0.2322045304919081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}