{"id":"W2010128338","doi":"10.1097/qad.0b013e3280187505","title":"Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug resistance mutations","year":2007,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"GlaxoSmithKline","keywords":"Reverse transcriptase; Resistance mutation; Virology; Biology; Nucleoside Reverse Transcriptase Inhibitor; Virus; RNA; Reverse-transcriptase inhibitor; Viral replication; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002931436,0.0003372906,0.0004312741,0.000221743,0.0001128797,0.0004504403,0.0002957667,0.0003940773,0.001688362],"category_scores_gemma":[0.0004811693,0.0001741651,0.0002421631,0.0001322134,0.0002447844,0.0002552582,0.0001246045,0.0004743677,0.0006286785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003153735,"about_ca_system_score_gemma":0.0001763887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003317072,"about_ca_topic_score_gemma":0.0003308431,"domain_scores_codex":[0.9995492,0.0001077091,0.00006414506,0.00007476794,0.0001482475,0.00005599646],"domain_scores_gemma":[0.9997124,0.00007635118,0.0001066316,0.00003994742,0.00003837121,0.0000262762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006248648,0.00002257891,0.0005629692,0.00003641031,0.00000671056,0.00004195128,0.00001198743,0.0000432544,0.9979145,0.00004087156,0.00001339493,0.00124288],"study_design_scores_gemma":[0.00001294758,0.0005974868,0.005573615,0.000007189132,0.00002170369,0.0008222322,0.00002110605,0.0005378838,0.9913755,0.00003119602,0.0009944192,0.000004597062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965016,0.001292021,0.001390297,0.00003758109,0.00001466191,0.00002152555,0.0001700662,0.00005216448,0.000520159],"genre_scores_gemma":[0.9959723,0.0003768099,0.002540347,0.00002973995,0.000009438954,0.00001560224,0.0003508365,0.00001497174,0.0006899151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001688362,"threshold_uncertainty_score":0.005648136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097403174987088,"score_gpt":0.2567079742645271,"score_spread":0.2457339425146562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}