{"id":"W2010128338","doi":"10.1097/qad.0b013e3280187505","title":"Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug resistance mutations","year":2007,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"GlaxoSmithKline","keywords":"Reverse transcriptase; Resistance mutation; Virology; Biology; Nucleoside Reverse Transcriptase Inhibitor; Virus; RNA; Reverse-transcriptase inhibitor; Viral replication; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004938374,0.0001023566,0.0001879149,0.00007778004,0.0001200877,0.000007458837,0.0000519441,0.00002878183,0.00005327391],"category_scores_gemma":[0.00008690804,0.0000682933,0.00005197388,0.0002279097,0.0001443388,0.0000456413,0.00001049409,0.00008573822,0.00001226088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000296041,"about_ca_system_score_gemma":0.00006030149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001206675,"about_ca_topic_score_gemma":0.00002542168,"domain_scores_codex":[0.9991895,0.00002845602,0.0002583018,0.0001567978,0.0001890865,0.0001778866],"domain_scores_gemma":[0.999421,0.0002041021,0.00005868752,0.0001791819,0.00005844502,0.00007856842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003040837,0.001844038,0.7216048,0.0006086814,0.001102733,0.00115272,0.1413008,0.000006711376,0.01632181,0.03405409,0.05056434,0.02839843],"study_design_scores_gemma":[0.03170703,0.001191501,0.3398827,0.001735662,0.0031581,0.0002019488,0.07031713,0.0002167988,0.1153399,0.001938466,0.4329558,0.001354957],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814219,0.0007672683,0.001096743,0.004425284,0.00007739542,0.0003554797,0.00001336246,0.00003261067,0.01180997],"genre_scores_gemma":[0.9719085,0.00003287792,0.004410608,0.0002166381,0.000021785,0.00001012817,0.00002828042,0.000009926114,0.02336126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3823915,"threshold_uncertainty_score":0.278492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097403174987088,"score_gpt":0.2567079742645271,"score_spread":0.2457339425146562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}