{"id":"W2010140924","doi":"10.1016/j.jmb.2012.01.008","title":"Catalytic Activity and Acyl-Chain Selectivity of Diacylglycerol Kinase ɛ Are Modulated by Residues in and near the Lipoxygenase-Like Motif","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Diacylglycerol kinase; Biochemistry; Phosphatidic acid; Phosphorylation; Chemistry; Mutant; Gene isoform; Amino acid; Enzyme; Peptide sequence; Protein kinase C; Biology; Gene; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001975258,0.0001685004,0.0001713631,0.0001269563,0.0001486256,0.0004050149,0.0002501414,0.0002190607,0.0009702565],"category_scores_gemma":[0.000236654,0.0001777653,0.0001759189,0.0001054644,0.000289839,0.0001703348,0.0001729392,0.0004387705,0.0004438309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003612695,"about_ca_system_score_gemma":0.0002002501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004195415,"about_ca_topic_score_gemma":0.0005098119,"domain_scores_codex":[0.9998838,0.00002055193,0.000009738467,0.00002417149,0.00002292659,0.00003880256],"domain_scores_gemma":[0.9998901,0.00002625069,0.00002826706,0.000008172432,0.00001033026,0.00003684435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006738986,0.00002510255,0.0006024856,0.00001507615,0.000005493675,0.00003053985,0.00002066241,0.00007424763,0.9969222,0.0004007365,0.00003366157,0.001195799],"study_design_scores_gemma":[0.0001144265,0.000161822,0.01465072,0.000007843105,0.00002557621,0.0004041441,0.00005281537,0.004313503,0.9784153,0.000335548,0.001500762,0.00001763279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982122,0.0002946973,0.0009162979,0.0000549893,0.00001179319,0.00000466643,0.00004677455,0.000009960642,0.0004486635],"genre_scores_gemma":[0.9987587,0.0001343707,0.0004293793,0.00002424864,0.000004313182,0.000004305874,0.0001354888,0.000005124908,0.0005041933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009702565,"threshold_uncertainty_score":0.003245771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006429979947964304,"score_gpt":0.2403715963078609,"score_spread":0.2339416163598966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}