{"id":"W2010168649","doi":"10.1016/s0014-5793(02)03614-1","title":"A cluster of familial Creutzfeldt–Jakob disease mutations recapitulate conserved residues in Doppel: a case of molecular mimicry?","year":2002,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Missense mutation; PRNP; Biology; Mutant; Genetics; Mutation; Conserved sequence; Allele; Peptide sequence; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002039968,0.0005316553,0.0003776593,0.0005172308,0.0003863861,0.0003832677,0.0002757338,0.0008503068,0.0006544415],"category_scores_gemma":[0.0007301915,0.0002198917,0.0002083089,0.0002941859,0.0007537374,0.0002398311,0.0003820966,0.0003763344,0.0003078147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003324604,"about_ca_system_score_gemma":0.0001447385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004897815,"about_ca_topic_score_gemma":0.00080803,"domain_scores_codex":[0.9997953,0.00003322009,0.00002209906,0.00005539674,0.00004895808,0.00004504934],"domain_scores_gemma":[0.9996166,0.00006872602,0.0001376134,0.00006242222,0.00002367182,0.00009090481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00166361,0.0002093701,0.03491941,0.0001310735,0.0001108491,0.3003279,0.0009098992,0.001206938,0.6359753,0.004540138,0.0008040016,0.01920151],"study_design_scores_gemma":[0.0002159417,0.001412118,0.0772782,0.00002193776,0.0001364396,0.8131364,0.0003352543,0.003174382,0.09617761,0.00156325,0.006486057,0.0000624298],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977549,0.0001545361,0.0008045481,0.00013257,0.000008689115,0.00001544978,0.00003639814,0.00004625631,0.001046718],"genre_scores_gemma":[0.998843,0.0000747762,0.0006166255,0.00006305543,0.00001163614,0.000004540034,0.00002668832,0.00001024033,0.0003493214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008503068,"threshold_uncertainty_score":0.0024122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235434264694031,"score_gpt":0.2400240947101843,"score_spread":0.2276697520632439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}