{"id":"W2010192073","doi":"10.1371/journal.pone.0079771","title":"Alzheimer’s Disease: Analyzing the Missing Heritability","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":344,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Medical Research Council; Hersenstichting; Universitat de Barcelona; Bristol-Myers Squibb; North Bristol NHS Trust; Howard Hughes Medical Institute; Eisai; National Cancer Institute; Stichting MS Research; Eli Lilly and Company; Alzheimer's Research Trust; Northern California Institute for Research and Education; Medpace; National Center for Research Resources; F. Hoffmann-La Roche; Wellcome Trust; Brigham Young University; GlaxoSmithKline; Pfizer; Novartis; Elan; Newcastle University; Office of Research and Development; U.S. Department of Veterans Affairs; Synarc; Dana Foundation; Alzheimer's Association; AstraZeneca","keywords":"International HapMap Project; Genome-wide association study; Single-nucleotide polymorphism; Biology; Genetics; Heritability; Genotyping; Missing heritability problem; Genetic association; Apolipoprotein E; Disease; Genotype; Phenotype; Medicine; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01734103,0.0009049683,0.001794822,0.002320966,0.001002217,0.001496433,0.001057679,0.0009019111,0.002678422],"category_scores_gemma":[0.0613886,0.0005777199,0.001493068,0.004524169,0.0009542297,0.001354321,0.001717132,0.001673241,0.0002699925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005331818,"about_ca_system_score_gemma":0.0009789957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009862305,"about_ca_topic_score_gemma":0.00769639,"domain_scores_codex":[0.9903973,0.006480448,0.0004721456,0.001587766,0.0006729708,0.0003893585],"domain_scores_gemma":[0.9375585,0.05182512,0.002407484,0.00626163,0.0009982584,0.0009490167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007918866,0.0001180854,0.8872916,0.0003238338,0.004531953,0.001442977,0.0008816943,0.007614736,0.001365044,0.009719383,0.00421812,0.08170067],"study_design_scores_gemma":[0.0003780909,0.0003343023,0.8590952,0.0003149306,0.004550956,0.002078723,0.001097021,0.05455222,0.001105985,0.07029601,0.00607113,0.0001253921],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9027523,0.007150326,0.07699017,0.004523458,0.0002028525,0.00007183995,0.006434542,0.0002493427,0.001625184],"genre_scores_gemma":[0.9767594,0.001292234,0.01844315,0.0003127919,0.0001613951,0.00008357118,0.002617729,0.00005086436,0.0002788696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01734103,"threshold_uncertainty_score":0.09170926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09381486849326316,"score_gpt":0.3092584720187067,"score_spread":0.2154436035254435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}