{"id":"W2010192873","doi":"10.1002/cam4.22","title":"Strategies for discovery and validation of methylated and hydroxymethylated <scp>DNA</scp> biomarkers","year":2012,"lang":"en","type":"review","venue":"Cancer Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; Methylation; Computational biology; Biology; CpG site; Biomarker; Epigenomics; Bisulfite sequencing; Biomarker discovery; Methylated DNA immunoprecipitation; DNA; Genetics; Proteomics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008468082,0.001298586,0.001492398,0.002818838,0.0005261399,0.001799793,0.00191509,0.002165341,0.001626895],"category_scores_gemma":[0.009318504,0.0008345195,0.0009912136,0.001627528,0.001264271,0.001337048,0.001861004,0.002055221,0.002292349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009144612,"about_ca_system_score_gemma":0.002441646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008849949,"about_ca_topic_score_gemma":0.001093952,"domain_scores_codex":[0.9946728,0.001772833,0.0003901542,0.001167815,0.00173458,0.000261832],"domain_scores_gemma":[0.9955748,0.001245249,0.000748941,0.000677114,0.001516968,0.000236966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0004775889,0.0002666946,0.009469875,0.002555973,0.0003364422,0.0006368123,0.0003163783,0.004080909,0.805857,0.0109691,0.003469651,0.1615636],"study_design_scores_gemma":[0.0001095884,0.001290865,0.008952154,0.0006255747,0.0005238978,0.001427908,0.0002297514,0.02481693,0.8573215,0.01285084,0.09168416,0.0001668757],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.09623553,0.038581,0.8430727,0.003150695,0.0007725682,0.003459211,0.003720018,0.001996933,0.009011395],"genre_scores_gemma":[0.2929035,0.02256808,0.6620433,0.003172004,0.0005069951,0.004689096,0.007156871,0.0002947985,0.006665373],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.008468082,"threshold_uncertainty_score":0.04478401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04849839516977614,"score_gpt":0.354034621942621,"score_spread":0.3055362267728449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}