{"id":"W2010192873","doi":"10.1002/cam4.22","title":"Strategies for discovery and validation of methylated and hydroxymethylated <scp>DNA</scp> biomarkers","year":2012,"lang":"en","type":"review","venue":"Cancer Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; Methylation; Computational biology; Biology; CpG site; Biomarker; Epigenomics; Bisulfite sequencing; Biomarker discovery; Methylated DNA immunoprecipitation; DNA; Genetics; Proteomics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005135188,0.0003209565,0.0008561435,0.0001354705,0.00004840036,0.00002036453,0.0001000226,0.0004048914,0.000004588655],"category_scores_gemma":[0.000171453,0.0002421492,0.0001035048,0.0001649652,0.0002399769,0.00001329124,0.00006137985,0.00009335896,1.828026e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001887869,"about_ca_system_score_gemma":0.0001827369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005491619,"about_ca_topic_score_gemma":0.000008255976,"domain_scores_codex":[0.9986195,0.0001177463,0.0005081358,0.0003988869,0.0001270073,0.0002287259],"domain_scores_gemma":[0.9988769,0.0001812102,0.0004712681,0.0002473375,0.0001141413,0.0001090931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002343552,0.00003346005,0.0001014097,0.0151943,0.001112595,6.511755e-7,0.0002420476,0.000006271251,0.1138095,0.0001694807,0.0004607358,0.8688461],"study_design_scores_gemma":[0.0007445065,0.0004251772,0.00004983699,0.002268522,0.001940415,0.000003484644,0.000168507,0.00001276671,0.03438798,0.0002998506,0.9595244,0.0001745823],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01387584,0.983147,0.001589926,0.00002012151,0.0003066886,0.0006896228,0.00013494,0.000007243418,0.0002286307],"genre_scores_gemma":[0.007653775,0.9902948,0.0001902517,0.00001325081,0.0004218029,0.0001194274,0.001050796,0.00004940211,0.0002065269],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9590636,"threshold_uncertainty_score":0.9874557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04849839516977614,"score_gpt":0.354034621942621,"score_spread":0.3055362267728449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}