{"id":"W2010247113","doi":"10.1021/cb400095v","title":"Targeted Delivery of Doxorubicin to Mitochondria","year":2013,"lang":"en","type":"letter","venue":"ACS Chemical Biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Mitochondrion; Doxorubicin; Nucleic acid; Topoisomerase; Efflux; Biology; Organelle; Cancer cell; Biochemistry; Mitochondrial DNA; Cell biology; DNA; Chemistry; Cancer; Genetics; Chemotherapy; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002238481,0.0002834007,0.0003109856,0.0001273393,0.0003219343,0.0005085296,0.0003376197,0.003283184,0.002471122],"category_scores_gemma":[0.0006232918,0.0001471287,0.0002302089,0.0000789134,0.0004683761,0.0004355484,0.0003591027,0.001340383,0.001720156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001092267,"about_ca_system_score_gemma":0.0002523274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004080835,"about_ca_topic_score_gemma":0.000763508,"domain_scores_codex":[0.9997604,0.00005165373,0.00001230145,0.00004907207,0.0000953014,0.00003122428],"domain_scores_gemma":[0.9998272,0.00007633541,0.0000215377,0.00002153761,0.00003319559,0.00002016262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008097592,0.0002693374,0.001452086,0.001281658,0.0001037431,0.01274449,0.0002912668,0.001782637,0.4372244,0.05042902,0.3177154,0.1758962],"study_design_scores_gemma":[0.0005319728,0.001056395,0.001653337,0.0001818878,0.000059611,0.01126458,0.0001177556,0.006173474,0.2628437,0.008410396,0.7076392,0.00006764288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2423549,0.1311784,0.05991489,0.3791321,0.04396009,0.0009300951,0.001099989,0.001842292,0.1395873],"genre_scores_gemma":[0.6767728,0.06004932,0.01836305,0.1209963,0.009447598,0.0009358975,0.0003762479,0.0001191481,0.1129396],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003283184,"threshold_uncertainty_score":0.008266687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01070336151060923,"score_gpt":0.2420137492037608,"score_spread":0.2313103876931516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}