{"id":"W2010266614","doi":"10.1016/j.micinf.2010.06.006","title":"Escape of intracellular Shigella from autophagy requires binding to cholesterol through the type III effector, IcsB","year":2010,"lang":"en","type":"article","venue":"Microbes and Infection","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Beijing Advanced Innovation Center for Structural Biology, Tsinghua University; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; Effector; Autophagy; Secretion; Shigella; Microbiology; Shigella flexneri; Type three secretion system; Cell biology; Virulence; Molecular biology; Genetics; Bacteria; Salmonella; Biochemistry; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169802,0.0001383138,0.0002247497,0.00008849939,0.000165142,0.00004549029,0.00004204915,0.0001464611,0.0002520524],"category_scores_gemma":[0.00005909879,0.00009693187,0.00007057632,0.0002682736,0.0000774379,0.0001135627,0.00004960974,0.0002672253,0.00004596225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001976539,"about_ca_system_score_gemma":0.00002228613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003385858,"about_ca_topic_score_gemma":0.0002643485,"domain_scores_codex":[0.99928,0.000032606,0.0002248124,0.0002180468,0.00008293443,0.0001616142],"domain_scores_gemma":[0.9994417,0.00005997498,0.00007996634,0.0002667893,0.00008629712,0.00006524926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000501833,0.00008456089,0.0129511,0.00004018477,0.00005226942,9.692217e-7,0.0005179651,0.000006141786,0.9776042,0.0001133231,0.0009152183,0.007663893],"study_design_scores_gemma":[0.0008828841,0.0005136524,0.07720859,0.0001295481,0.0001602451,0.00005185771,0.00005317449,0.00006808835,0.8265381,0.00004819123,0.09421469,0.0001310097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962236,0.0002275174,0.0007145716,0.0003462529,0.001518278,0.0003866607,0.000007893306,0.00005273347,0.0005225032],"genre_scores_gemma":[0.9983802,0.0002642385,0.0004086331,0.0002246573,0.0004215398,0.00001613328,0.00002306953,0.00001988051,0.0002416418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1510661,"threshold_uncertainty_score":0.5118427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187760051883671,"score_gpt":0.259914257557281,"score_spread":0.2480366570384443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}