{"id":"W2010278974","doi":"10.1177/0091270010382915","title":"Pharmacogenetics of Intravenous and Oral Busulfan in Hematopoietic Cell Transplant Recipients","year":2010,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Busulfan; Medicine; Dosing; Pharmacology; Population; Hematopoietic stem cell transplantation; Pharmacokinetics; Pharmacogenetics; Internal medicine; Gastroenterology; Oncology; Transplantation; Genotype; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009274013,0.000196802,0.0003881688,0.0003537641,0.0001576031,0.0004987676,0.0001550944,0.0003344679,0.0004627529],"category_scores_gemma":[0.001947867,0.0001397016,0.0003443517,0.000393991,0.0002313992,0.0001439624,0.0001772383,0.0004249595,0.000158007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795593,"about_ca_system_score_gemma":0.000188688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006291179,"about_ca_topic_score_gemma":0.0005026787,"domain_scores_codex":[0.999385,0.0002576991,0.00005684112,0.00010166,0.0001295984,0.00006911955],"domain_scores_gemma":[0.9989153,0.0003968598,0.000459532,0.00007058122,0.00005175206,0.0001058784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001745389,0.00008331067,0.9703311,0.000020199,0.0001780059,0.0002935401,0.0000932586,0.0005747422,0.01169149,0.0001552206,0.0001142863,0.01471959],"study_design_scores_gemma":[0.00003316583,0.0009259285,0.9912723,0.000007113436,0.0001124485,0.001042587,0.0000564519,0.001904007,0.00409088,0.0001519627,0.0003970768,0.000006077091],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988376,0.0004038269,0.0003275659,0.00004069578,0.00000290454,0.000006475149,0.00003432918,0.000006296967,0.0003402983],"genre_scores_gemma":[0.9996046,0.00007867414,0.0001491791,0.00002888227,0.000004450206,0.000003546444,0.00004813237,0.000003669742,0.00007888127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009274013,"threshold_uncertainty_score":0.004904628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04259470473159469,"score_gpt":0.3938264752781396,"score_spread":0.3512317705465449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}