{"id":"W2010291063","doi":"10.1016/j.jmb.2011.05.034","title":"A Concerted Mechanism for Opening the GDP Binding Pocket and Release of the Nucleotide in Hetero-Trimeric G-Proteins","year":2011,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Université de Montpellier; Centre National de la Recherche Scientifique; Agence Nationale de la Recherche; Institut national de la recherche scientifique","keywords":"Context (archaeology); Trimer; Helix (gastropod); Biophysics; Molecular dynamics; Chemistry; Crystallography; Protein structure; Function (biology); Biology; Biochemistry; Dimer; Computational chemistry; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007785087,0.0003841287,0.0008540309,0.000319875,0.0009791356,0.001082111,0.001250974,0.001373969,0.001326852],"category_scores_gemma":[0.0005609468,0.000726938,0.0006177429,0.0001478925,0.001226193,0.001726449,0.0009767114,0.001365845,0.0005259216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006173801,"about_ca_system_score_gemma":0.0004724352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000213408,"about_ca_topic_score_gemma":0.0003183775,"domain_scores_codex":[0.9998088,0.00001968851,0.00001901508,0.00005389768,0.00004592341,0.00005264402],"domain_scores_gemma":[0.9997161,0.00007150339,0.0000411486,0.00008091731,0.00002177455,0.0000685718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001101195,0.0003408181,0.001834218,0.0004008194,0.00009474644,0.002684087,0.000443461,0.007717118,0.9092642,0.05873957,0.001522573,0.01585721],"study_design_scores_gemma":[0.001007002,0.002576034,0.009690844,0.00007479418,0.0001529356,0.005254813,0.0007219214,0.1486509,0.7768115,0.04404047,0.01069357,0.0003252513],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971184,0.001645038,0.02214885,0.001194441,0.0003257949,0.0001079335,0.00008470855,0.000626489,0.002682747],"genre_scores_gemma":[0.9912031,0.000509434,0.006360411,0.0001329917,0.000056941,0.00007656866,0.00006398649,0.00002330665,0.001573342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001373969,"threshold_uncertainty_score":0.004479468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223446492272231,"score_gpt":0.2553976213948035,"score_spread":0.2331631564720812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}