{"id":"W2010292024","doi":"10.1242/dev.098590","title":"Transcription factors <i>lhx1/5-1</i> and <i>pitx</i> are required for the maintenance and regeneration of serotonergic neurons in planarians","year":2013,"lang":"en","type":"article","venue":"Development","topic":"Planarian Biology and Electrostimulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Biology; Serotonergic; Planarian; Regeneration (biology); Transcription factor; Cell biology; Neuroscience; Proneural genes; Anatomy; Genetics; Gene; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009067987,0.0000745459,0.000077386,0.00002033843,0.00007234885,0.00000840526,0.00003856228,0.00007998696,0.000001344806],"category_scores_gemma":[0.00002217471,0.00005391164,0.00001136735,0.00003118013,0.0000390901,0.000006108324,0.00001063947,0.00003238902,2.538885e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006681198,"about_ca_system_score_gemma":0.0000244181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002304736,"about_ca_topic_score_gemma":0.0002500146,"domain_scores_codex":[0.9995403,0.00002281303,0.0001407792,0.0001527864,0.00003008417,0.0001131855],"domain_scores_gemma":[0.9998121,0.00001932863,0.00005407341,0.00006664428,0.00002792398,0.00001998906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001270605,0.00002447928,0.04441425,0.00002796285,0.00003261224,3.376e-7,0.0004031732,0.0002237105,0.9493073,0.0002117894,0.002570482,0.002656811],"study_design_scores_gemma":[0.0008460681,0.00013872,0.6563797,0.00002125393,0.00001117626,0.00000731573,0.0001252821,0.000867783,0.3249718,0.0002161724,0.01626609,0.0001485817],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926351,0.0002746594,0.00403329,0.002571286,0.00004621681,0.0004049365,0.00001108354,0.000003197317,0.00002025907],"genre_scores_gemma":[0.998693,0.0001438963,0.0002443219,0.0005473889,0.00001508802,0.00007773629,0.0001549959,0.000005004143,0.0001185612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6243355,"threshold_uncertainty_score":0.2198453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337879139652047,"score_gpt":0.2091491296778779,"score_spread":0.1957703382813574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}