{"id":"W2010299451","doi":"10.1038/nsmb.1768","title":"Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation","year":2010,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; Gene silencing; Cell biology; Genetics; Argonaute; Psychological repression; microRNA; RNA-binding protein; RNA interference; RNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003417748,0.0004394014,0.0004669395,0.0002120762,0.0005306681,0.0005475231,0.0004214877,0.0007233993,0.002622007],"category_scores_gemma":[0.0002540128,0.0003139793,0.0004319829,0.0001648102,0.0003807819,0.0003680382,0.0003414433,0.00112037,0.001016875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005832434,"about_ca_system_score_gemma":0.0004179474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007878285,"about_ca_topic_score_gemma":0.001196446,"domain_scores_codex":[0.9998573,0.00002768357,0.00001220197,0.00003765539,0.0000372547,0.00002783321],"domain_scores_gemma":[0.9998642,0.0000415437,0.00002595463,0.00001476852,0.00001090269,0.0000426091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006018947,0.0001035606,0.001014404,0.0001175954,0.00004193613,0.002407038,0.0001030375,0.003323828,0.9767626,0.006846526,0.0009257335,0.007751952],"study_design_scores_gemma":[0.0001428752,0.0002207468,0.004897742,0.00002083693,0.0000673478,0.002080647,0.0001364116,0.02494312,0.9498289,0.002550565,0.01506171,0.0000490321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731331,0.002056497,0.01786122,0.0007861098,0.0001818506,0.00003593652,0.0002987811,0.0004919444,0.005154528],"genre_scores_gemma":[0.9930754,0.0003845158,0.004529258,0.0001624893,0.0000203808,0.00001216448,0.000232925,0.00003244177,0.001550443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002622007,"threshold_uncertainty_score":0.008771479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004830198020452623,"score_gpt":0.314074445665215,"score_spread":0.3092442476447623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}