{"id":"W2010299451","doi":"10.1038/nsmb.1768","title":"Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation","year":2010,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; Gene silencing; Cell biology; Genetics; Argonaute; Psychological repression; microRNA; RNA-binding protein; RNA interference; RNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453584,0.0002811961,0.0002107492,0.0001621746,0.0002437973,0.00005568569,0.0005025843,0.0008964046,0.00004294418],"category_scores_gemma":[0.0003397453,0.0001908029,0.0001220331,0.000248903,0.0002560931,0.00001462764,0.0001968025,0.001612074,0.000007424081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003678174,"about_ca_system_score_gemma":0.00006390594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003949991,"about_ca_topic_score_gemma":0.00296087,"domain_scores_codex":[0.9982784,0.000230724,0.00031888,0.0005549869,0.0001597511,0.0004572037],"domain_scores_gemma":[0.9991005,0.00002920309,0.0001324983,0.0004773004,0.0001525348,0.0001079861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007118467,0.000004673548,0.007133285,0.000006286708,0.00003829251,0.00001207077,0.0001103052,0.00002180721,0.9882572,0.002122955,0.00006118534,0.002160792],"study_design_scores_gemma":[0.001127468,0.0002893174,0.06477153,0.00001228875,0.00001502447,0.00009536592,0.0001770883,0.0008565756,0.9220808,0.004322262,0.005802431,0.0004498905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969774,0.001013848,0.00008014819,0.0007594259,0.0006718785,0.0003324092,0.000006549564,0.00001987535,0.0001384978],"genre_scores_gemma":[0.9976507,0.00002111804,0.0003343583,0.0006932764,0.0003497606,0.00001981844,0.0008300288,0.00002807905,0.00007282387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0661764,"threshold_uncertainty_score":0.7780718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004830198020452623,"score_gpt":0.314074445665215,"score_spread":0.3092442476447623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}