{"id":"W2010305809","doi":"10.1038/sj.leu.2401779","title":"Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro","year":2000,"lang":"en","type":"article","venue":"Leukemia","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pediatric Oncology Group","funders":"National Cancer Institute; National Institutes of Health","keywords":"CD22; Immunotoxin; Propidium iodide; CD19; Cytotoxicity; B cell; Monoclonal antibody; Cancer research; Antigen; Cytotoxic T cell; CD33; Fluorescein isothiocyanate; Saporin; Acute lymphocytic leukemia; Molecular biology; Medicine; Immunology; Antibody; Chemistry; In vitro; Leukemia; Biology; Apoptosis; CD34; Lymphoblastic Leukemia; Stem cell; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003586784,0.0005026374,0.0007474276,0.0003446848,0.0001927921,0.00005120275,0.0003850993,0.0006632708,0.0003525138],"category_scores_gemma":[0.00004229242,0.0004958228,0.0001353196,0.0004244711,0.0002186265,0.0002696934,0.0001319497,0.0009205079,0.0007445575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001629592,"about_ca_system_score_gemma":0.0002515313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005328137,"about_ca_topic_score_gemma":0.0001533725,"domain_scores_codex":[0.997247,0.0003469548,0.0006245492,0.0007662974,0.00007563704,0.0009395482],"domain_scores_gemma":[0.9989371,0.0003117435,0.0001727499,0.0004931581,0.00003146795,0.00005374846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009552467,0.00009103202,0.0005342013,0.00003570784,0.000120087,0.0001521415,0.001184465,0.0005167406,0.9613003,0.00004187497,0.0001362525,0.03493195],"study_design_scores_gemma":[0.009628557,0.0003535782,0.02693539,0.0005259604,0.00007982933,0.0001458087,0.0005608439,0.0008862114,0.951813,0.0003452135,0.007731246,0.0009943356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943864,0.002381254,0.00006369605,0.00003589858,0.0006094615,0.0008889697,0.0001053993,0.0001066874,0.001422189],"genre_scores_gemma":[0.9949635,0.001309157,0.0002195913,0.0004057829,0.00003929151,0.0001873897,0.00008416393,0.00006516543,0.002725922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03393761,"threshold_uncertainty_score":0.9997494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004229346843111661,"score_gpt":0.2020443545210451,"score_spread":0.1978150076779334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}