{"id":"W2010305809","doi":"10.1038/sj.leu.2401779","title":"Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro","year":2000,"lang":"en","type":"article","venue":"Leukemia","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pediatric Oncology Group","funders":"National Cancer Institute; National Institutes of Health","keywords":"CD22; Immunotoxin; Propidium iodide; CD19; Cytotoxicity; B cell; Monoclonal antibody; Cancer research; Antigen; Cytotoxic T cell; CD33; Fluorescein isothiocyanate; Saporin; Acute lymphocytic leukemia; Molecular biology; Medicine; Immunology; Antibody; Chemistry; In vitro; Leukemia; Biology; Apoptosis; CD34; Lymphoblastic Leukemia; Stem cell; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003232444,0.0003931738,0.0003821545,0.0003700072,0.0002398348,0.0004562759,0.000289876,0.0004163437,0.00141886],"category_scores_gemma":[0.0002995938,0.0002380891,0.0002912742,0.0003095805,0.0002213794,0.0002863502,0.0003560375,0.0007645211,0.0004759228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003040823,"about_ca_system_score_gemma":0.0002216506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006440007,"about_ca_topic_score_gemma":0.001050664,"domain_scores_codex":[0.9996908,0.00008121476,0.0000217498,0.00002261084,0.0000718004,0.0001118814],"domain_scores_gemma":[0.999691,0.0001326794,0.00004019672,0.00005036146,0.0000288251,0.00005698348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005731776,0.0002134404,0.0005389692,0.00005952266,0.00001786572,0.0001194525,0.00004537634,0.0002458505,0.9944453,0.0002836517,0.0001338443,0.003323618],"study_design_scores_gemma":[0.0001087493,0.001290621,0.005110401,0.00001039899,0.00003301195,0.0003830796,0.00004777923,0.0008430714,0.9892747,0.00007942937,0.002815358,0.000003475481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990935,0.00272563,0.002902871,0.00008021652,0.00005062706,0.00009149619,0.0002069714,0.0000646264,0.002942423],"genre_scores_gemma":[0.9920339,0.002055724,0.00223456,0.00006508212,0.00002780104,0.00008341867,0.0007628496,0.00002310835,0.002713562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141886,"threshold_uncertainty_score":0.004746556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004229346843111661,"score_gpt":0.2020443545210451,"score_spread":0.1978150076779334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}