{"id":"W2010348633","doi":"10.1007/s00280-003-0619-7","title":"Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide","year":2003,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Pharmacology; Pharmacokinetics; Etoposide; Chemistry; Medicine; Chemotherapy; Cancer; Internal medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293991,0.0003042192,0.0006172204,0.0002154211,0.0001660136,0.0002450559,0.0002145217,0.00037121,0.001159073],"category_scores_gemma":[0.000476048,0.0001887586,0.0002721635,0.0001787816,0.0002328741,0.0002339807,0.0001241077,0.000487083,0.0001828742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588908,"about_ca_system_score_gemma":0.0002552051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005041,"about_ca_topic_score_gemma":0.00109043,"domain_scores_codex":[0.9998342,0.00009375308,0.00001095048,0.00001927836,0.00001645225,0.00002537023],"domain_scores_gemma":[0.9998603,0.00002787362,0.00004442132,0.00001616998,0.00001243917,0.00003875461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1509534,0.0007358926,0.05945197,0.0002331959,0.0004763488,0.003926401,0.000557406,0.001839853,0.7374977,0.0003673087,0.0006505604,0.04331],"study_design_scores_gemma":[0.003734198,0.0542219,0.2933338,0.00005649215,0.0008743806,0.009080141,0.0008017289,0.009684943,0.6227521,0.000223353,0.005170664,0.00006634707],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982144,0.001129385,0.0001595104,0.00004449532,0.00001233495,0.00001138626,0.00007198511,0.00001241951,0.0003441542],"genre_scores_gemma":[0.9993211,0.0002210107,0.0001547241,0.0000158887,0.000005643334,0.000003867087,0.00009053996,0.000003117853,0.0001842084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159073,"threshold_uncertainty_score":0.003877461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904655638343964,"score_gpt":0.3137058671868466,"score_spread":0.2946593108034069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}