{"id":"W2010364403","doi":"10.1016/j.cell.2005.03.016","title":"Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis","year":2005,"lang":"en","type":"article","venue":"Cell","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":278,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences","keywords":"Biology; Cytochrome c; Apoptosis; Cytochrome; Cytochrome b; Apoptosome; Cell biology; Molecular biology; Biochemistry; Caspase; Gene; Programmed cell death; Mitochondrial DNA; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009694989,0.00007872143,0.0001178769,0.00004032021,0.00003752856,0.000005017277,0.00006250852,0.00008488368,0.00002414911],"category_scores_gemma":[0.000007705129,0.00006122296,0.00007208907,0.00006449903,0.00004329515,0.000003667278,0.00004215248,0.00002781686,5.278629e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001683885,"about_ca_system_score_gemma":0.00001444571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000398368,"about_ca_topic_score_gemma":0.000007359868,"domain_scores_codex":[0.9993871,0.00002314635,0.0002400104,0.0001665909,0.00008061766,0.0001025383],"domain_scores_gemma":[0.9996064,0.000009794259,0.0001228198,0.0001955196,0.0000445076,0.00002094054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004078354,0.00007757259,0.0001081112,0.00006022822,0.00000825953,1.146445e-8,0.0000438967,0.0002468082,0.9982601,0.0001224476,0.0001366295,0.0008951067],"study_design_scores_gemma":[0.000820115,0.0001729601,0.02118101,0.000029176,0.0000248369,8.385067e-7,0.00002728545,0.0003871111,0.9753488,0.0001730623,0.001754292,0.00008053934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919916,0.0002768104,0.006838073,0.00006029836,0.00007915233,0.0004292956,0.00002062049,0.000002111251,0.0003019803],"genre_scores_gemma":[0.9983343,0.0001166621,0.0006744884,0.00001064513,0.0001107497,0.00002394933,0.0000593299,0.000009527494,0.0006603635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02291137,"threshold_uncertainty_score":0.24966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227755722668139,"score_gpt":0.2250796446593113,"score_spread":0.2128020874326299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}