{"id":"W2010364403","doi":"10.1016/j.cell.2005.03.016","title":"Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis","year":2005,"lang":"en","type":"article","venue":"Cell","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":278,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences","keywords":"Biology; Cytochrome c; Apoptosis; Cytochrome; Cytochrome b; Apoptosome; Cell biology; Molecular biology; Biochemistry; Caspase; Gene; Programmed cell death; Mitochondrial DNA; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002150191,0.0004609533,0.0004638307,0.0006204451,0.0003478112,0.000680435,0.0005922136,0.0005593754,0.001098735],"category_scores_gemma":[0.0002916869,0.0003890097,0.0003555493,0.000350296,0.000497941,0.0005927106,0.0003689018,0.001616822,0.0004265968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007648848,"about_ca_system_score_gemma":0.0003481919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005319339,"about_ca_topic_score_gemma":0.0009431258,"domain_scores_codex":[0.9996974,0.00002213867,0.00002667989,0.00005879551,0.00009725206,0.00009775549],"domain_scores_gemma":[0.9994241,0.0001237512,0.000130551,0.0001123817,0.00005378043,0.0001554699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008116803,0.000009075397,0.00007252606,0.000007309889,0.000002774217,0.0000287675,0.000003361755,0.00003488587,0.999126,0.0002386171,0.00001107632,0.0003845183],"study_design_scores_gemma":[0.00001199715,0.00004329714,0.002419746,0.000002154349,0.00001128763,0.0004213482,0.0000131807,0.000707301,0.9956118,0.0001320873,0.000621989,0.000003914749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895681,0.001206228,0.007189016,0.0001751503,0.00003486461,0.00001623893,0.000327035,0.0001318587,0.001351507],"genre_scores_gemma":[0.9940659,0.0004560864,0.002836875,0.00005415688,0.000009981719,0.0000165646,0.0003367682,0.00004726571,0.002176479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001098735,"threshold_uncertainty_score":0.005549729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227755722668139,"score_gpt":0.2250796446593113,"score_spread":0.2128020874326299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}