{"id":"W2010385141","doi":"10.1021/bp049807b","title":"Enhanced Production of Monomeric Interferon-β by CHO Cells through the Control of Culture Conditions","year":2005,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chinese hamster ovary cell; Sodium butyrate; Glycosylation; Cell culture; Glycerol; Biochemistry; Chemistry; Glycoprotein; Titer; Recombinant DNA; Dimethyl sulfoxide; Interferon; Bioprocess; Biology; Antibody; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003377089,0.0005118828,0.0004863694,0.0001998179,0.0001913579,0.0004614985,0.0003514609,0.0002836193,0.0005311908],"category_scores_gemma":[0.0002553806,0.0001665962,0.0002862378,0.0003137546,0.0001967221,0.0002736348,0.0003308774,0.0005605534,0.0004762173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000446424,"about_ca_system_score_gemma":0.0002839759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008505543,"about_ca_topic_score_gemma":0.001427007,"domain_scores_codex":[0.9996688,0.00006749856,0.00005645548,0.0000678565,0.0001038447,0.00003549096],"domain_scores_gemma":[0.9998456,0.00002888369,0.00004136416,0.00003103906,0.00004007321,0.00001298699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002946004,0.00000743711,0.00006182334,0.00001591367,0.000002140644,0.00001107802,0.000009474907,0.00002688706,0.9994045,0.00001769209,0.00001001439,0.0004034692],"study_design_scores_gemma":[0.000009231768,0.0001102523,0.001003049,0.000003122166,0.00001194169,0.00007655657,0.00001314242,0.0003985277,0.9969941,0.00001747144,0.001357911,0.000004730011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805013,0.002404896,0.01322426,0.000150072,0.00009588589,0.0001627426,0.0009355877,0.0002268545,0.002298446],"genre_scores_gemma":[0.9608992,0.002226477,0.03058746,0.0001278096,0.00004075032,0.0003156378,0.001781043,0.0001094458,0.003912089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008505543,"threshold_uncertainty_score":0.003239036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004553963520655083,"score_gpt":0.2520882523734782,"score_spread":0.2475342888528231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}