{"id":"W2010385141","doi":"10.1021/bp049807b","title":"Enhanced Production of Monomeric Interferon-β by CHO Cells through the Control of Culture Conditions","year":2005,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chinese hamster ovary cell; Sodium butyrate; Glycosylation; Cell culture; Glycerol; Biochemistry; Chemistry; Glycoprotein; Titer; Recombinant DNA; Dimethyl sulfoxide; Interferon; Bioprocess; Biology; Antibody; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004762781,0.0001243029,0.0001572468,0.00002741699,0.00008658333,0.000005108808,0.0002336022,0.0002897138,0.00002168635],"category_scores_gemma":[0.0000272514,0.00008736771,0.00008980535,0.0001227059,0.0005957825,0.00000670847,0.00006907304,0.0001074158,0.000004209609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008803987,"about_ca_system_score_gemma":0.0000225726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006018228,"about_ca_topic_score_gemma":0.000003219203,"domain_scores_codex":[0.99924,0.00004247745,0.0002308266,0.0002581891,0.00006820545,0.0001602741],"domain_scores_gemma":[0.9992644,0.00000438448,0.0002246747,0.0003946084,0.00009116803,0.00002081254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008025367,0.0001960801,0.00007616478,0.00001841164,0.00007928679,9.328095e-8,0.00005768414,0.0001041125,0.9795262,0.0002235728,0.0155292,0.004108918],"study_design_scores_gemma":[0.0003730909,0.0004905076,0.00003564762,0.00001763695,0.00002703537,0.000004049101,0.0001061518,0.00002007689,0.9522725,0.0000701133,0.04649265,0.00009052242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852259,0.006342028,0.005407641,0.001749506,0.0003306628,0.0006308742,0.0001037085,0.00004129005,0.0001684566],"genre_scores_gemma":[0.9984441,0.0005838507,0.0002570991,0.0001084214,0.0001105884,0.0001529617,0.0000437929,0.00001127294,0.0002878433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03096346,"threshold_uncertainty_score":0.3562752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004553963520655083,"score_gpt":0.2520882523734782,"score_spread":0.2475342888528231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}