{"id":"W2010388612","doi":"10.1038/gt.2008.54","title":"Immunity to adeno-associated virus vectors in animals and humans: a continued challenge","year":2008,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Heart and Stroke Foundation of Canada","keywords":"Adeno-associated virus; Genetic enhancement; Biology; Immune system; Vector (molecular biology); Transgene; Gene delivery; Immunity; Virology; Virus; Viral vector; Innate immune system; Acquired immune system; Immunology; Capsid; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006056523,0.0006344638,0.001399087,0.0003111837,0.0001504565,0.0000429772,0.0006661122,0.0006767472,0.00006365781],"category_scores_gemma":[0.00008394045,0.0005856044,0.0003406421,0.0004081792,0.0001229011,0.000003432046,0.0002086494,0.000484164,0.00004200725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001132672,"about_ca_system_score_gemma":0.0003514466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001425509,"about_ca_topic_score_gemma":0.001171462,"domain_scores_codex":[0.9966562,0.0009327113,0.0006078387,0.0008201816,0.0002881052,0.000694928],"domain_scores_gemma":[0.9985381,0.00005432666,0.0002225551,0.0008768731,0.0001060561,0.000202125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001350338,0.0004215438,0.00002677149,0.000354587,0.0008011272,0.00005284503,0.0005027729,0.000001714755,0.06897413,0.000002724891,0.000736835,0.9267746],"study_design_scores_gemma":[0.00169359,0.005565066,0.0001693583,0.0007126993,0.00003318595,0.00002467901,0.00002021107,4.535936e-7,0.01049006,0.00001772533,0.9804053,0.0008676333],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2164089,0.7820525,0.000001489848,0.00002660654,0.00006572327,0.001213729,0.0001167548,0.00002334327,0.00009099231],"genre_scores_gemma":[0.003771517,0.9946986,0.00003068925,0.0001567277,0.0002340508,0.0003632115,0.0003379226,0.0001579352,0.0002493263],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9796685,"threshold_uncertainty_score":0.9996595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06828153963896955,"score_gpt":0.3638678367695622,"score_spread":0.2955862971305926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}