{"id":"W2010399667","doi":"10.1158/1078-0432.ccr-07-4879","title":"The Type 1 Insulin-Like Growth Factor Receptor Pathway","year":2008,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":447,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Cancer Research UK; Wellcome Trust","keywords":"Insulin-like growth factor 1 receptor; Insulin receptor; Insulin-like growth factor; Receptor tyrosine kinase; Medicine; Targeted therapy; Tyrosine kinase; Insulin-Like Growth Factor Receptor; Receptor; Signal transduction; Cancer; Pharmacology; Cancer research; Insulin; Biology; Insulin resistance; Growth factor; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.003246713,0.0008547772,0.003512173,0.0004681713,0.0009981458,0.0001508445,0.00154132,0.001724877,0.0007857124],"category_scores_gemma":[0.00812972,0.0004900416,0.001792612,0.002628106,0.001848083,0.0001325243,0.0007269779,0.007988887,0.003960705],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008319237,"about_ca_system_score_gemma":0.008481524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002485955,"about_ca_topic_score_gemma":0.00002766468,"domain_scores_codex":[0.9890295,0.002407109,0.002813513,0.001547077,0.002406802,0.001795968],"domain_scores_gemma":[0.9881519,0.005941994,0.0005547378,0.001920044,0.002152027,0.001279299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000386158,0.000279196,0.0004346757,0.002990542,0.0005216436,0.0001031584,0.00005188904,6.028018e-9,0.000001146614,0.0001145123,0.1788397,0.8162774],"study_design_scores_gemma":[0.0009229864,0.001348028,0.0005441274,0.004434522,0.0001880116,0.00004851364,0.00002478947,0.000001090645,0.000005044319,0.00005057494,0.9919327,0.0004995403],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005290661,0.9883097,0.000001178542,0.0008055926,0.004141718,0.00271848,0.000213382,0.000148725,0.003132107],"genre_scores_gemma":[0.0001527546,0.9840028,0.00004934909,0.000372778,0.004371014,0.0005662689,0.000221861,0.0002698736,0.0099933],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8157779,"threshold_uncertainty_score":0.9997551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.389277735689035,"score_gpt":0.5307568062604718,"score_spread":0.1414790705714369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}