{"id":"W2010423033","doi":"10.1021/ac801206s","title":"Aptamer-Based Affinity Chromatographic Assays for Thrombin","year":2008,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Chemistry; Thrombin; Chromatography; Detection limit; Affinity chromatography; Elution; Absorbance; Biochemistry; Molecular biology; Enzyme; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007927121,0.0009082265,0.0008469212,0.001069032,0.0004070035,0.0005216467,0.001175259,0.0009251314,0.00234988],"category_scores_gemma":[0.0015426,0.0004194377,0.0005053959,0.0006441609,0.0002534283,0.0003878725,0.0006269185,0.001447301,0.003101945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005371397,"about_ca_system_score_gemma":0.0004194891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007619704,"about_ca_topic_score_gemma":0.001380478,"domain_scores_codex":[0.9980115,0.0003672627,0.0001537095,0.0003474887,0.0008362919,0.0002837441],"domain_scores_gemma":[0.9989541,0.000296261,0.00009288923,0.0001001759,0.0004340085,0.0001225253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004663625,0.00005048408,0.0001795069,0.00009449458,0.00001599703,0.00003392555,0.00001765049,0.00009672005,0.9932232,0.0001957753,0.0003087542,0.005736915],"study_design_scores_gemma":[0.00001702723,0.0001298874,0.00114341,0.00001177679,0.0000274741,0.000350534,0.00001155249,0.003207073,0.9905021,0.0002082611,0.004371268,0.00001956674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2361642,0.01666962,0.7293469,0.000786852,0.0005651593,0.001180812,0.002098485,0.003950969,0.009236877],"genre_scores_gemma":[0.5462083,0.01025277,0.4131677,0.001190591,0.0002183124,0.001439216,0.004476034,0.0002766697,0.0227704],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00234988,"threshold_uncertainty_score":0.007861137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196567041878946,"score_gpt":0.2814243175706163,"score_spread":0.2594586471518269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}