{"id":"W2010423033","doi":"10.1021/ac801206s","title":"Aptamer-Based Affinity Chromatographic Assays for Thrombin","year":2008,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Chemistry; Thrombin; Chromatography; Detection limit; Affinity chromatography; Elution; Absorbance; Biochemistry; Molecular biology; Enzyme; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139487,0.00021587,0.0002532802,0.00002857399,0.000162822,0.00001364936,0.0001952975,0.0002763262,0.00001377595],"category_scores_gemma":[0.0002215507,0.0001965583,0.0003624774,0.0001943409,0.0003451278,0.000002810484,0.00004865391,0.0001222562,0.000002986619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001586781,"about_ca_system_score_gemma":0.00009119289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004625693,"about_ca_topic_score_gemma":0.000002531926,"domain_scores_codex":[0.9987734,0.00001819656,0.0002446517,0.0004777627,0.000165139,0.0003208538],"domain_scores_gemma":[0.9991273,0.00003499968,0.00008343884,0.0004713162,0.0001428843,0.0001400953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007071082,0.0001900975,0.002279646,0.00004248155,0.0001071222,0.000009497182,0.000001883508,0.00000980861,0.9881673,0.00003506235,0.008919891,0.0001664315],"study_design_scores_gemma":[0.0004148303,0.0001095187,0.0003920972,0.00001187322,0.00007123271,0.00003684807,0.00001023759,0.001112564,0.9879482,0.0001517308,0.009449989,0.0002908684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826612,0.0001240237,0.01272712,0.0003095256,0.00002235151,0.0001389726,0.00004944468,0.000113299,0.003854017],"genre_scores_gemma":[0.9925024,0.00006712716,0.005782851,0.0003450833,0.0001975627,0.00001852237,0.0003096253,0.00002528593,0.0007515724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009841121,"threshold_uncertainty_score":0.8015416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196567041878946,"score_gpt":0.2814243175706163,"score_spread":0.2594586471518269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}