{"id":"W2010449137","doi":"10.1053/j.semnuclmed.2008.02.007","title":"Applying Neuroimaging Ligands to Study Major Depressive Disorder","year":2008,"lang":"en","type":"review","venue":"Seminars in Nuclear Medicine","topic":"Treatment of Major Depression","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Anhedonia; Neuroimaging; Medicine; Major depressive disorder; Antidepressant; Radioligand; Monoamine neurotransmitter; Psychiatry; Mood; Neuroscience; Internal medicine; Serotonin; Psychology; Receptor; Anxiety; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008686777,0.001102946,0.001945652,0.001579727,0.0002320018,0.0008901737,0.001099914,0.001265033,0.002435328],"category_scores_gemma":[0.001119146,0.000365253,0.0006026708,0.001570192,0.0006924292,0.000883835,0.0005410737,0.002023834,0.001443105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006093694,"about_ca_system_score_gemma":0.000980493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001823043,"about_ca_topic_score_gemma":0.004120365,"domain_scores_codex":[0.9998711,0.00003240016,0.00002089341,0.00002467838,0.0000374012,0.00001349153],"domain_scores_gemma":[0.9995246,0.0003117932,0.0000510622,0.00001512736,0.00006632651,0.00003101385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002068282,0.00014466,0.0002873083,0.009208267,0.0002136072,0.0004097149,0.00004418947,0.0003367751,0.001941006,0.001893366,0.02819341,0.9571208],"study_design_scores_gemma":[0.0003622649,0.0003606313,0.001894006,0.004521816,0.0007106116,0.002955358,0.00009103642,0.0002073018,0.001083706,0.002444252,0.9853258,0.00004323312],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001451902,0.998578,0.0001938341,0.0002577613,0.0001564596,0.000006037312,0.00001216642,0.00000844382,0.0006421931],"genre_scores_gemma":[0.0009568526,0.997609,0.0003553903,0.0003802978,0.0001743049,0.00001022097,0.00002546345,0.000001768465,0.0004866628],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002435328,"threshold_uncertainty_score":0.008147001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03256698516355656,"score_gpt":0.3493503816604757,"score_spread":0.3167833964969192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}